Gene

mstna

ID

ZDB-GENE-050208-735

Name

myostatin a

Symbol

mstna Nomenclature History

Previous Names

mstn2 (1)
gdf8l
myostatin-2 (1)
si:dkeyp-84a8.5
zfMSTN-2 (1)

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to enable cytokine activity. Acts upstream of or within immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; eye; heart; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in myostatin-related muscle hypertrophy. Orthologous to human MSTN (myostatin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Wang et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mstna Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
myostatin-related muscle hypertrophy	Alliance	?Muscle hypertrophy	614160

Associated With mstna Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017948	Transforming growth factor beta, conserved site
Domain	IPR001111	TGF-beta, propeptide
Domain	IPR001839	Transforming growth factor-beta, C-terminal
Family	IPR015615	Transforming growth factor-beta-related
Homologous_superfamily	IPR029034	Cystine-knot cytokine