Gene
hdac8
- ID
- ZDB-GENE-040426-2772
- Name
- histone deacetylase 8
- Symbol
- hdac8 Nomenclature History
- Previous Names
-
- wu:fd19a02
- zgc:66196 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have histone deacetylase activity. Predicted to be involved in histone H3 deacetylation; histone H4 deacetylation; and positive regulation of transcription by RNA polymerase II. Predicted to localize to histone deacetylase complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7144626 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Cornelia de Lange syndrome 5 | Alliance | Cornelia de Lange syndrome 5 | 300882 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
Cornelia de Lange syndrome | AB + MO2-hdac8 | standard conditions | Bottai et al., 2018 |
Cornelia de Lange syndrome | AB + MO3-hdac8 | standard conditions | Bottai et al., 2018 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR011613 | GH15-like domain |
Domain | IPR023801 | Histone deacetylase domain |
Domain | IPR045583 | Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain |
Family | IPR000286 | Histone deacetylase family |
Family | IPR003084 | Histone deacetylase |
Family | IPR008734 | Phosphorylase kinase alpha/beta subunit |
Family | IPR050284 | Histone deacetylase and polyamine deacetylase |
Homologous_superfamily | IPR008928 | Six-hairpin glycosidase superfamily |
Homologous_superfamily | IPR012341 | Six-hairpin glycosidase-like superfamily |
Homologous_superfamily | IPR023696 | Ureohydrolase domain superfamily |
Homologous_superfamily | IPR037138 | Histone deacetylase domain superfamily |
Domain Details Per Protein
Protein | Length | GH15-like domain | Histone deacetylase | Histone deacetylase and polyamine deacetylase | Histone deacetylase domain | Histone deacetylase domain superfamily | Histone deacetylase family | Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain | Phosphorylase kinase alpha/beta subunit | Six-hairpin glycosidase-like superfamily | Six-hairpin glycosidase superfamily | Ureohydrolase domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q7SXM0
|
378 | |||||||||||
UniProtKB:A0A8M2BE34
|
311 | |||||||||||
UniProtKB:A0A286YAZ5
|
1232 | |||||||||||
UniProtKB:E7F4R5
|
1219 |
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-hdac8 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
4 |
Plasmids
No data available