ZFIN ID: ZDB-GENE-040426-2772
Gene Name: histone deacetylase 8
Gene Symbol: hdac8    Nomenclature History

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Previous Names: wu:fd19a02, zgc:66196 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have histone deacetylase activity. Predicted to be involved in histone H3 deacetylation; histone H4 deacetylation; and positive regulation of transcription by RNA polymerase II. Predicted to localize to histone deacetylase complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8).
Genome Resources: Alliance (1),  Gene:406740 (1), 
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7144626]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la026136Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10754 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14948 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31597 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44675 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-hdac8 N/A 1
    MO2-hdac8 N/A 2
    MO3-hdac8 N/A 1
    DISEASE ASSOCIATED WITH hdac8 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Cornelia de Lange syndrome 5 Alliance Cornelia de Lange syndrome 5 300882
    DISEASE ASSOCIATED WITH hdac8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process carbohydrate metabolic process (more)
    Cellular Component cytoplasm (more)
    Molecular Function calmodulin binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript hdac8-205 (1)    Ensembl 566
    mRNA hdac8-201 (1)    Ensembl 1935
    hdac8-203 (1)    Ensembl 725
    ncRNA hdac8-002 (1)    Ensembl 475
    hdac8-004 (1)    Ensembl 528
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-hdac8 polyclonal IgG Rabbit Santa Cruz Biotechnology, Inc.
    3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hdac8 No data available
    MARKER RELATIONSHIPS
    hdac8 Contained in: [BAC] DKEY-29B6 (1) (order this)
    hdac8 Encodes: [EST] fd19a02 (1), IMAGE:7144626 (1)
    [cDNA] MGC:66196 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213431 (1) 1935 nt
    Genomic GenBank:CR318655 (1) 247390 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A286YAZ5 (1) 1232 aa
    Sequence Information (all 20)
    ORTHOLOGY for hdac8 ( Chr: 7 )
    CITATIONS (32)