Gene

hdac8

ID
ZDB-GENE-040426-2772
Name
histone deacetylase 8
Symbol
hdac8 Nomenclature History
Previous Names
  • wu:fd19a02
  • zgc:66196 (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have histone deacetylase activity. Predicted to be involved in histone H3 deacetylation; histone H4 deacetylation; and positive regulation of transcription by RNA polymerase II. Predicted to localize to histone deacetylase complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hdac8 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Cornelia de Lange syndrome 5 Alliance Cornelia de Lange syndrome 5 300882
Associated With hdac8 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011613 GH15-like domain
Domain IPR023801 Histone deacetylase domain
Family IPR000286 Histone deacetylase family
Family IPR003084 Histone deacetylase
Family IPR008734 Phosphorylase kinase alpha/beta subunit
Homologous_superfamily IPR008928 Six-hairpin glycosidase superfamily
Homologous_superfamily IPR012341 Six-hairpin glycosidase-like superfamily
Homologous_superfamily IPR023696 Ureohydrolase domain superfamily
Homologous_superfamily IPR037138 Histone deacetylase domain superfamily
Domain Details Per Protein
Protein Length GH15-like domain Histone deacetylase Histone deacetylase domain Histone deacetylase domain superfamily Histone deacetylase family Phosphorylase kinase alpha/beta subunit Six-hairpin glycosidase-like superfamily Six-hairpin glycosidase superfamily Ureohydrolase domain superfamily
UniProtKB:E7F4R5 1219
UniProtKB:A0A1L1QZM1 282
UniProtKB:F1QAZ7 213
UniProtKB:Q7SXM0 378
UniProtKB:F1R9J0 378
UniProtKB:A0A1L1QZN3 62
UniProtKB:A0A286YAZ5 1232
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-hdac8 polyclonal IgG Rabbit
  • WB
Santa Cruz Biotechnology, Inc.
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations