Gene

zic3

ID

ZDB-GENE-030708-2

Name

zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)

Symbol

zic3 Nomenclature History

Previous Names

cb807 (1)
id:ibd2176
wu:fj52a10
wu:fq33c12

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in anterior/posterior axis specification and determination of left/right symmetry. Predicted to localize to nucleus. Used to study right atrial isomerism; spina bifida; and visceral heterotaxy. Human ortholog(s) of this gene implicated in X-linked VACTERL association; situs inversus; and visceral heterotaxy. Is expressed in several structures, including central nervous system; mesoderm; neural keel; neural plate; and presumptive structure. Orthologous to human ZIC3 (Zic family member 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

25 figures from 11 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb807 (25 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With zic3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
visceral heterotaxy	Alliance	Congenital heart defects, nonsyndromic, 1, X-linked	306955
visceral heterotaxy	Alliance	Heterotaxy, visceral, 1, X-linked	306955
X-linked VACTERL association	Alliance	VACTERL association, X-linked	314390

Associated With zic3 Via Experimental Models

Human Disease	Fish	Conditions	Citations
right atrial isomerism	TU + MO4-zic3	standard conditions	Li et al., 2018
spina bifida	AB + MO1-zic3	standard conditions	Cast et al., 2012
visceral heterotaxy	AB + MO1-zic3	standard conditions	Cast et al., 2012

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013087	Zinc finger C2H2-type
Domain	IPR041643	ZIC protein, zinc finger domain
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily

Domain Details Per Protein

Protein	Length	ZIC protein, zinc finger domain	Zinc finger C2H2 superfamily	Zinc finger C2H2-type
UniProtKB:Q6PV84 InterPro	448

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	zic3-201 (1) Ensembl	Havana	3711 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-zic3	polyclonal	zic3	IgG	Rabbit			1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations