Gene

zic3

ID
ZDB-GENE-030708-2
Name
zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)
Symbol
zic3 Nomenclature History
Previous Names
  • cb807 (1)
  • id:ibd2176
  • wu:fj52a10
  • wu:fq33c12
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior axis specification and determination of left/right symmetry. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; mesoderm; neural keel; neural plate; and presumptive structure. Used to study right atrial isomerism; spina bifida; and visceral heterotaxy. Human ortholog(s) of this gene implicated in X-linked VACTERL association; situs inversus; and visceral heterotaxy. Orthologous to human ZIC3 (Zic family member 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
24 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With zic3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
visceral heterotaxy Alliance Congenital heart defects, nonsyndromic, 1, X-linked 306955
visceral heterotaxy Alliance Heterotaxy, visceral, 1, X-linked 306955
X-linked VACTERL association Alliance VACTERL association, X-linked 314390
Associated With zic3 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Domain IPR041643 ZIC protein, zinc finger domain
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length ZIC protein, zinc finger domain Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:Q6PV84 448
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-zic3 polyclonal IgG Rabbit
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations