Gene

pcdh15a

ID

ZDB-GENE-030616-3

Name

protocadherin-related 15a

Symbol

pcdh15a Nomenclature History

Previous Names

orb
orbiter
si:bac7cse.1
si:xx-bac7cse.1

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity. Involved in several processes, including cilium assembly; detection of mechanical stimulus involved in sensory perception of sound; and hair cell differentiation. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in Usher syndrome type 1D; Usher syndrome type 1F; and autosomal recessive nonsyndromic deafness 23. Is expressed in several structures, including hair cell; hatching gland; polster; sensory system; and trunk. Orthologous to human PCDH15 (protocadherin related 15).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

24 figures from 13 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu634 (4 images)
eu1029 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 17 figures from 9 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pcdh15a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 23	Alliance	Deafness, autosomal recessive 23	609533
Usher syndrome type 1D	Alliance	Usher syndrome, type 1D/F digenic	601067
Usher syndrome type 1F	Alliance	Usher syndrome, type 1F	602083

Associated With pcdh15a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020894	Cadherin conserved site
Domain	IPR002126	Cadherin-like
Domain	IPR041149	Extracellular cadherin domain
Family	IPR050971	Cadherin domain-containing protein
Homologous_superfamily	IPR015919	Cadherin-like superfamily
Homologous_superfamily	IPR030718	Extracellular cadherin domain superfamily

Domain Details Per Protein

Protein	Length	Cadherin conserved site	Cadherin domain-containing protein	Cadherin-like	Cadherin-like superfamily	Extracellular cadherin domain	Extracellular cadherin domain superfamily
UniProtKB:Q5ICW6 InterPro	1796
UniProtKB:A0A8M6Z9I8 InterPro	1714
UniProtKB:A0A1V0D7A1 InterPro	1726
UniProtKB:A0A8M3B5H0 InterPro	1806
UniProtKB:A0A8M3AZF2 InterPro	1801
UniProtKB:A0A8M6Z1M2 InterPro	1713
UniProtKB:A0A8M6Z1L7 InterPro	1727
UniProtKB:A0A8M6Z3R5 InterPro	1725
UniProtKB:A0A8M6Z284 InterPro	1726

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pcdh15a-201 (1) Ensembl	Ensembl	6,495 nt	Select Tool
mRNA	pcdh15a-202 (1) Ensembl	Ensembl	5,391 nt	Select Tool ZFIN BLAST
mRNA	pcdh15a-203 (1) Ensembl	Ensembl	5,181 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-pcdh15a	polyclonal	pcdh15a		Rabbit	IHC	Proteintech	2
Ab2-pcdh15a	monoclonal	pcdh15a		Mouse	IHC		5

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations