ZFIN ID: ZDB-GENE-030616-3
Gene Name: protocadherin-related 15a
Gene Symbol: pcdh15a    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: orb, orbiter, si:bac7cse.1, si:xx-bac7cse.1

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity. Involved in several processes, including cilium assembly; detection of mechanical stimulus involved in sensory perception of sound; and hair cell differentiation. Predicted to localize to integral component of plasma membrane. Is expressed in several structures, including hair cell; hatching gland; polster; sensory system; and trunk. Human ortholog(s) of this gene implicated in Usher syndrome type 1D; Usher syndrome type 1F; and autosomal recessive nonsyndromic deafness 23. Orthologous to human PCDH15 (protocadherin related 15).
Genome Resources: Alliance (1),  Gene:368476 (1),  Ensembl(GRCz11):ENSDARG00000098257 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la012402Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018628Tg Transgenic Insertion Unknown Unknown DNA
    psi7 Point Mutation Unknown Splice Site, Frameshift
    sa483 Point Mutation Unknown Splice Site ENU
    sa1509 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2682 Point Mutation Unknown Splice Site ENU
    sa5868 Point Mutation Unknown Premature Stop ENU
    sa13589 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19068 Point Mutation Unknown Splice Site ENU
    sa22367 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35571 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42279 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t288 Point Mutation Unknown Missense ENU
    t23281 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • t25708 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tc256e Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • th263b Point Mutation Unknown Premature Stop ENU
    DISEASE ASSOCIATED WITH pcdh15a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive nonsyndromic deafness 23 Alliance Deafness, autosomal recessive 23 609533
    Usher syndrome type 1D Alliance Usher syndrome, type 1D/F digenic 601067
    Usher syndrome type 1F Alliance Usher syndrome, type 1F 602083
    DISEASE ASSOCIATED WITH pcdh15a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cilium assembly (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein binding (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pcdh15a-201 (1)    Ensembl 6495
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-pcdh15a polyclonal Rabbit IHC Proteintech
    2
    Ab2-pcdh15a monoclonal Mouse IHC 4
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pcdh15a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-6myo6b:pcdh15a-EGFP) myo6b EGFPpcdh15a Danio rerio 1 1
    Tg2(-6myo6b:pcdh15a-EGFP) myo6b EGFPpcdh15a Danio rerio 1 2
    Tg3(-6myo6b:pcdh15a-EGFP) myo6b EGFPpcdh15a Danio rerio 1 1
    Tg4(-6myo6b:pcdh15a-EGFP) myo6b EGFPpcdh15a Danio rerio 1 1
    Tg5(-6myo6b:pcdh15a-EGFP) myo6b EGFPpcdh15a Danio rerio 1 1
    Tg6(-6myo6b:pcdh15a-EGFP) myo6b EGFPpcdh15a Danio rerio 1 1
    MARKER RELATIONSHIPS
    pcdh15a Contained in: [BAC] CH73-54D9 (1), CH73-176C21 (1), CH73-182C23 (1), CH73-283N9 (1), CH211-151G17 (1), CH211-170I2 (1), DKEY-257M21 (1) (order this), DKEY-274K7 (1) (order this), XX-BAC6CSE, XX-BAC7CSE (1)
    pcdh15a Encodes: [EST] eu634 (1), eu1029 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001012482 (1) 6521 nt
    Genomic GenBank:BX548002 (1) 149569 nt
    Select Tool
    Polypeptide UniProtKB:Q5ICW6 (1) 1796 aa
    Sequence Information (all 52)
    ORTHOLOGY for pcdh15a ( Chr: 13 )
    CITATIONS (47)