Gene

pcdh15a

ID
ZDB-GENE-030616-3
Name
protocadherin-related 15a
Symbol
pcdh15a Nomenclature History
Previous Names
  • orb
  • orbiter
  • si:bac7cse.1
  • si:xx-bac7cse.1
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity. Involved in several processes, including cilium assembly; detection of mechanical stimulus involved in sensory perception of sound; and hair cell differentiation. Predicted to localize to integral component of plasma membrane. Is expressed in several structures, including hair cell; hatching gland; polster; sensory system; and trunk. Human ortholog(s) of this gene implicated in Usher syndrome type 1D; Usher syndrome type 1F; and autosomal recessive nonsyndromic deafness 23. Orthologous to human PCDH15 (protocadherin related 15).
Genome Resources
Note
None
Expression
All Expression Data
22 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pcdh15a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 23 Alliance Deafness, autosomal recessive 23 609533
Usher syndrome type 1D Alliance Usher syndrome, type 1D/F digenic 601067
Usher syndrome type 1F Alliance Usher syndrome, type 1F 602083
Associated With pcdh15a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020894 Cadherin conserved site
Domain IPR002126 Cadherin-like
Domain IPR041149 Extracellular cadherin domain
Family IPR030718 Protocadherin-15
Homologous_superfamily IPR015919 Cadherin-like superfamily
Domain Details Per Protein
Protein Length Cadherin conserved site Cadherin-like Cadherin-like superfamily Extracellular cadherin domain Protocadherin-15
UniProtKB:Q5ICW6 1796
UniProtKB:A0A1V0D7A1 1726
UniProtKB:Q7ZZ87 479
UniProtKB:Q8AW61 623
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pcdh15a polyclonal Rabbit
  • IHC
Proteintech
2
Ab2-pcdh15a monoclonal Mouse
  • IHC
5
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations