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ZIRC
ZFIN ID: ZDB-GENE-030616-3
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Gene Name: protocadherin-related 15a
Gene Symbol: pcdh15a
Sequence Ontology ID : SO:0000704

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Previous Names: orb, orbiter, si:bac7cse.1, si:xx-bac7cse.1

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(Including Attributions)
Location: Chr: 13 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have calcium ion binding activity. Involved in several processes, including cilium assembly; detection of mechanical stimulus involved in sensory perception of sound; and hair cell  ...
GENE EXPRESSION
All Expression Data: 20 figures from 9 publications
Directly Submitted Expression Data: 6 figures (4 images) from Thisse et al., 2005 [eu634]
  1 figure (1 image) from Thisse et al., 2005 [eu1029]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la012402Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la018628Tg Transgenic Insertion Unknown Unknown DNA
    psi7 Point Mutation Unknown Splice Site, Frameshift
    sa483 Point Mutation Unknown Splice Site ENU
    sa1509 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa2682 Point Mutation Unknown Splice Site ENU
    sa5868 Point Mutation Unknown Premature Stop ENU
    sa13589 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa19068 Point Mutation Unknown Splice Site ENU
    sa22367 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa35571 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa42279 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • t288 Point Mutation Unknown Missense ENU
    t23281 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • t25708 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • tc256e Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • th263b Point Mutation Unknown Premature Stop ENU
    Targeting reagents:
    PHENOTYPE
    Data: 14 figures from 6 publications
    Observed in:
    DISEASE ASSOCIATED WITH pcdh15a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    autosomal recessive nonsyndromic deafness 23 Deafness, autosomal recessive 23 609533
    Usher syndrome type 1D Usher syndrome, type 1D/F digenic 601067
    Usher syndrome type 1F Usher syndrome, type 1F 602083
    DISEASE ASSOCIATED WITH pcdh15a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cilium assembly (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002126 (1)
  • InterPro:IPR015919 (1)
  • InterPro:IPR020894 (1)
  • InterPro:IPR030718 (1)
  • InterPro:IPR041149 (1)
    		•
  • PROSITE:PS00232 (1)
    		•
  • Pfam:PF00028 (1)
  • Pfam:PF18432 (1)
    		•
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA pcdh15a-201 (1) 6495
    Select Tool
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM pcdh15a
    MARKER RELATIONSHIPS
    pcdh15aContained in: [BAC] CH73-54D9 (1) (order this), CH73-176C21 (1) (order this), CH73-182C23 (1) (order this), CH73-283N9 (1) (order this), CH211-151G17 (1) (order this), CH211-170I2 (1) (order this), DKEY-257M21 (1) (order this), DKEY-274K7 (1) (order this), XX-BAC6CSE, XX-BAC7CSE (1)
    pcdh15aEncodes: [EST] eu634 (1), eu1029 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001012482 (1) 6521bp
    Select Tool
    Genomic GenBank:BX548002 (1) 149569bp
    Select Tool
    Polypeptide UniProtKB:Q5ICW6 (1) 1796aa
    Select Tool
    Sequence Clusters UniGene:61053 (1)
    Sequence Information (all 53)
    OTHER pcdh15a GENE PAGES
  • Alliance (1)
  • Gene:368476 (1)
  • VEGA:OTTDARG00000020950 (1)
  • Ensembl(GRCz11):ENSDARG00000098257 (1)
    • ORTHOLOGY for pcdh15a (Chr: 13)
    CITATIONS (45)