Gene

yap1

ID

ZDB-GENE-030131-9710

Name

Yes1 associated transcriptional regulator

Symbol

yap1 Nomenclature History

Previous Names

yap (1)
cb194 (1)
sb:cb194
si:ch211-181p1.5 (1)
si:dkey-3b8.3
wu:fc18c04
zgc:158380

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Involved in several processes, including animal organ development; fin regeneration; and regulation of gene expression. Localizes to chromatin and nucleus. Used to study coloboma. Human ortholog(s) of this gene implicated in uveal coloboma-cleft lip and palate-intellectual disability. Is expressed in several structures, including central nervous system; digestive system; ectoderm; fin; and mesoderm. Orthologous to human YAP1 (Yes1 associated transcriptional regulator).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

29 figures from 18 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb194 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 51 figures from 22 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With yap1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
uveal coloboma-cleft lip and palate-intellectual disability	Alliance	Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development	120433

Associated With yap1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
coloboma	yap1^nl13/nl13	standard conditions	Miesfeld et al., 2015

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001202	WW domain
Homologous_superfamily	IPR036020	WW domain superfamily

Domain Details Per Protein

Protein	Length	WW domain	WW domain superfamily
UniProtKB:Q1L8J7 InterPro	442
UniProtKB:A0A8M2BKX9 InterPro	404

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	yap1-201 (1) Ensembl	Havana	3940 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab2-yap1	monoclonal	yap1	IgG2a	Mouse	IHC	Santa Cruz Biotechnology, Inc.	7
Ab1-yap1	polyclonal	yap1		Rabbit	IHC WB	Cell Signaling Technology, Inc.	16

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations