Gene

yap1

ID
ZDB-GENE-030131-9710
Name
Yes1 associated transcriptional regulator
Symbol
yap1 Nomenclature History
Previous Names
  • yap (1)
  • cb194 (1)
  • sb:cb194
  • si:ch211-181p1.5 (1)
  • si:dkey-3b8.3
  • wu:fc18c04
  • zgc:158380
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Involved in several processes, including animal organ development; fin regeneration; and positive regulation of glutamate-ammonia ligase activity. Localizes to chromatin and nucleus. Is expressed in several structures, including central nervous system; digestive system; fin; mesoderm; and tail bud. Used to study coloboma. Human ortholog(s) of this gene implicated in uveal coloboma-cleft lip and palate-intellectual disability. Orthologous to human YAP1 (Yes1 associated transcriptional regulator).
Genome Resources
Note
None
Expression
All Expression Data
23 figures from 13 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
48 figures from 19 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With yap1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
uveal coloboma-cleft lip and palate-intellectual disability Alliance Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation 120433
Associated With yap1 Via Experimental Models
Human Disease Fish Conditions Citations
coloboma yap1nl13/nl13 standard conditions Miesfeld et al., 2015
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
Protein Length
UniProtKB:Q1L8J7 442
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-yap1 monoclonal IgG2a Mouse
  • IHC
Santa Cruz Biotechnology, Inc.
5
Ab1-yap1 polyclonal Rabbit
  • IHC
  • WB
Cell Signaling Technology, Inc.
10
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations