Gene
dcaf7
- ID
- ZDB-GENE-030131-9511
- Name
- ddb1 and cul4 associated factor 7
- Symbol
- dcaf7 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Acts upstream of or within cartilage development and embryonic viscerocranium morphogenesis. Located in nucleus. Is expressed in forebrain; head; hindbrain; and somite. Orthologous to human DCAF7 (DDB1 and CUL4 associated factor 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63940 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi3812Tg | Transgenic insertion | Exon 1 | Unknown | DNA | |
| la010737Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa14350 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33209 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 4 of 4
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Family | IPR045159 | WD repeat-containing protein DCAF7-like |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
1 - 5 of 5
Domain Details Per Protein
| Protein | Length | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily | WD repeat-containing protein DCAF7-like |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BBB0
|
343 | |||||
|
UniProtKB:Q7T3E0
|
342 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:GFP-dcaf7,myl7:EGFP) |
| 2 | Alvarado et al., 2016 |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-194J22 | ZFIN Curated Data | |
| Encodes | EST | fj83g06 | ||
| Encodes | cDNA | MGC:63940 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200069 (1) | 2289 nt | ||
| Genomic | GenBank:CU062431 (1) | 183293 nt | ||
| Polypeptide | UniProtKB:A0A8M2BBB0 (1) | 343 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Alvarado, E., Yousefelahiyeh, M., Alvarado, G., Shang, R., Whitman, T., Martinez, A., Yu, Y., Pham, A., Bhandari, A., Wang, B., Nissen, R.M. (2016) Wdr68 Mediates Dorsal and Ventral Patterning Events for Craniofacial Development. PLoS One. 11:e0166984
- Glenewinkel, F., Cohen, M.J., King, C.R., Kaspar, S., Bamberg-Lemper, S., Mymryk, J.S., Becker, W. (2016) The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2. Scientific Reports. 6:28241
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, B., Doan, D., Roman Petersen, Y., Alvarado, E., Alvarado, G., Bhandari, A., Mohanty, A., Mohanty, S., and Nissen, R.M. (2013) Wdr68 requires nuclear access for craniofacial development. PLoS One. 8(1):e54363
- Leong, I.U., Skinner, J.R., Shelling, A.N., and Love, D.R. (2010) Identification and expression analysis of kcnh2 genes in the zebrafish. Biochemical and Biophysical Research Communications. 396(4):817-824
- Mazmanian, G., Kovshilovsky, M., Yen, D., Mohanty, A., Mohanty, S., Nee, A., and Nissen, R.M. (2010) The zebrafish dyrk1b gene is important for endoderm formation. Genesis (New York, N.Y. : 2000). 48(1):20-30
- Hassel, D., Scholz, E.P., Trano, N., Friedrich, O., Just, S., Meder, B., Weiss, D.L., Zitron, E., Marquart, S., Vogel, B., Karle, C.A., Seemann, G., Fishman, M.C., Katus, H.A., and Rottbauer, W. (2008) Deficient zebrafish ether-à-go-go-related gene channel gating causes short-QT syndrome in zebrafish reggae mutants. Circulation. 117(7):866-875
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
1 - 10 of 13
Show