Gene

sik1

ID

ZDB-GENE-030131-9446

Name

salt-inducible kinase 1

Symbol

sik1 Nomenclature History

Previous Names

fj78h07
si:ch211-235e18.3
wu:fj78h07

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 30. Orthologous to several human genes including SIK1B (salt inducible kinase 1B (putative)).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sik1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental and epileptic encephalopathy 30	Alliance	Developmental and epileptic encephalopathy 30	616341

Associated With sik1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR015940	Ubiquitin-associated domain
Domain	IPR034672	Salt-Inducible kinase, catalytic domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Salt-Inducible kinase, catalytic domain	Serine/threonine-protein kinase, active site	Ubiquitin-associated domain
UniProtKB:B0S6K0 InterPro	811
UniProtKB:A0A0G2L7B5 InterPro	800
UniProtKB:A0A8M2BEV1 InterPro	420

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	sik1-201 (1) Ensembl	Ensembl	4,880 nt	Select Tool
mRNA	sik1-204 (1) Ensembl	Ensembl	5,691 nt	Select Tool ZFIN BLAST
ncRNA	sik1-002 (1) Ensembl	Ensembl	539 nt	Select Tool
ncRNA	sik1-003 (1) Ensembl	Ensembl	606 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations