Gene
gfra1b
- ID
- ZDB-GENE-010226-3
- Name
- gdnf family receptor alpha 1b
- Symbol
- gfra1b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor activity. Acts upstream of or within enteric nervous system development. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in nervous system; presumptive enteric nervous system; pronephric duct; and vagal neural crest. Human ortholog(s) of this gene implicated in renal agenesis. Orthologous to human GFRA1 (GDNF family receptor alpha 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Renal hypodysplasia/aplasia 4 | 619887 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GDNF/GAS1 | GDNF receptor alpha | Glial cell line-derived neurotrophic factor receptor | Glial cell line-derived neurotrophic factor receptor, alpha 1/2 |
|---|---|---|---|---|---|
|
UniProtKB:Q98TT8
|
481 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gfra1b-201
(1)
|
Ensembl | 1,556 nt | ||
| ncRNA |
gfra1b-002
(1)
|
Ensembl | 535 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-gfra1 | polyclonal | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
3 |
Plasmids
No data available