ZFIN ID: ZDB-GENE-010226-2
Gene Name: gdnf family receptor alpha 1a
Gene Symbol: gfra1a    Nomenclature History

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Previous Name: zgc:110129

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Exhibits MAP kinase kinase kinase activity. Involved in enteric nervous system development and protein-containing complex assembly. Predicted to localize to external side of plasma membrane and receptor complex. Is expressed in nervous system; presumptive enteric nervous system; pronephric duct; and vagal neural crest. Orthologous to human GFRA1 (GDNF family receptor alpha 1).
Genome Resources: Alliance (1),  Gene:79376 (1),  Ensembl(GRCz11):ENSDARG00000099732 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9341 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14181 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22274 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42179 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gfra1a N/A 2
    PHENOTYPE
    Data: Fig. 5 from Shepherd et al., 2004
    Observed in:
    DISEASE ASSOCIATED WITH gfra1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH gfra1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein-containing complex assembly (more)
    Cellular Component anchored component of membrane (more)
    Molecular Function MAP kinase kinase kinase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gfra1a-202 (1)    Ensembl 2211
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-gfra1 polyclonal Rabbit IHC Santa Cruz Biotechnology, Inc.
    3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gfra1a No data available
    MARKER RELATIONSHIPS
    gfra1a Contained in: [Fosmid] CH1073-126C3 (1)
    gfra1a Encodes: [cDNA] MGC:110129 (1), MGC:162478 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131730 (1) 1419 nt
    Genomic GenBank:CU633804 (1) 36517 nt
    Select Tool
    Polypeptide UniProtKB:A0A0H2UKX5 (1) 473 aa
    Sequence Information (all 31)
    ORTHOLOGY for gfra1a ( Chr: 13 )
    CITATIONS (32)