ZFIN ID: ZDB-GENE-001229-1

Gene Name:aminolevulinate, delta-, synthetase 2
Gene Symbol: alas2

Previous Names: sauternes(1) , sau(1) , alas-e, cb1063(1) , si:dkey-24f17none, si:dkey-24f17.4
Nomenclature History

---

GENE EXPRESSION:(current status)

All expression data:	9 figure(s) from 4 publications
Directly submitted expression data:	2 figure(s) (3 images) from Thisse et al., 2001 [cb1063]
	5 figure(s) (5 images) from Thisse et al., 2004 [MGC:65747]
Wild Type Stages, Structures:	Segmentation:1-4 somites (10.33h-11.66h) to Hatching:Long-pec (48.00h-60.00h)
	blood, pronephric duct, ventral mesoderm
Curated microarray expression:	GEO  (1)

---

MUTANTS AND TARGETED KNOCKDOWNS:

Mutant line(s):   3 genotypes
Allele(s):   tb223, ty121

Phenotype: (current status)

Data:	3 figures from 2 publications
Observed in:	anatomical system, basophilic erythroblast, blood, hemoglobin biosynthetic process, nucleate erythrocyte

Knockdown reagent: MO1-alas2 (1)

---

GENE PRODUCTS:

Gene Ontology

Ontology	GO Term
Biological Process	embryonic hemopoiesis (more)
Cellular Component	mitochondrial matrix (more)
Molecular Function	5-aminolevulinate synthase activity (more)

All GO Terms (14)

Protein Families, Domains and Sites:

InterPro:IPR001917 (1) InterPro:IPR004839 (1) InterPro:IPR010961 (1) InterPro:IPR015118 (1) InterPro:IPR015421 (1) InterPro:IPR015422 (1) InterPro:IPR015424 (1)

PROSITE:PS00599 (1)

Pfam:PF00155 (1) Pfam:PF09029 (1)

EC:2.3.1.37 (1)

Gene Product Description

---

SEGMENT (CLONE AND PROBE) RELATIONSHIPS:

alas2 Contained in	[BAC] DKEY-24F17 (1)    (order this) , DKEY-163F12 (1)    (order this)
alas2 Encodes	[EST] cb1063 (1)    (order this) [cDNA] MGC:65747 (1)    (order this)

---

SEQUENCE INFORMATION:

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131682 (1)	2540 bp	- Select Tool - ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX784023 (1)	231254 bp	- Select Tool - MegaBLAST
Polypeptide	UniProtKB:Q9YHT4 (1)	583 aa	- Select Tool - ZFIN BLAST Ensembl SIB BLAST
Sequence Clusters	UniGene:8180 (1)
All Sequence Information (12)

---

OTHER  alas2  GENE / MARKER PAGES:

Entrez Gene:64607 (1)

VEGA:OTTDARG00000020550 (1)

Ensembl(Zv8):ENSDARG00000038643 (1)

---

MAPPING INFORMATION:

LG:  8    Details

---

ORTHOLOGY:

				Evidence
Species	Symbol	Chromosome (Position)	Accession #	AA
Zebrafish	alas2	8
Human	ALAS2	X (p11.21)	OMIM:301300 Entrez Gene:212
Mouse	Alas2	X (63.00 cM)	MGI:87990 Entrez Gene:11656
Orthology Details

---

CITATIONS   (36)