ZFIN ID: ZDB-GENE-001229-1
Gene Name: aminolevulinate, delta-, synthase 2
Gene Symbol: alas2    Nomenclature History

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Previous Names: alas-e, sau (1), cb1063 (1), sauternes (1), si:dkey-24f17.4, si:dkey-24f17none

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have 5-aminolevulinate synthase activity. Involved in heme biosynthetic process; hemoglobin biosynthetic process; and hemopoiesis. Predicted to localize to mitochondrial inner membrane. Used to study sideroblastic anemia. Human ortholog(s) of this gene implicated in cutaneous porphyria; erythropoietic protoporphyria; hemochromatosis; sideroblastic anemia; and sideroblastic anemia 1. Is expressed in erythroid progenitor cell; hematopoietic system; mesoderm; and pronephric duct. Orthologous to human ALAS2 (5'-aminolevulinate synthase 2).
Genome Resources: Alliance (1),  Gene:64607 (1),  Ensembl(GRCz11):ENSDARG00000038643 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
tb223 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ty121 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-alas2 N/A 1
    MO2-alas2 N/A 2
    DISEASE ASSOCIATED WITH alas2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    erythropoietic protoporphyria Alliance Protoporphyria, erythropoietic, X-linked 300752
    sideroblastic anemia 1 Alliance Anemia, sideroblastic, 1 300751
    DISEASE ASSOCIATED WITH alas2 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    sideroblastic anemia alas2ty121/ty121 standard conditions Brownlie et al., 1998
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hemoglobin metabolic process (more)
    Cellular Component mitochondrial inner membrane (more)
    Molecular Function 5-aminolevulinate synthase activity (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA alas2-201 (1)    Ensembl 2544
    ncRNA alas2-002 (1)    Ensembl 618
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-alas2 polyclonal IgG Rabbit WB GeneTex
    3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM alas2 No data available
    MARKER RELATIONSHIPS
    alas2 Contained in: [BAC] DKEY-24F17 (1) (order this), DKEY-163F12 (1) (order this)
    alas2 Encodes: [EST] cb1063 (1) (order this)
    [cDNA] MGC:65747 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131682 (1) 2540 nt
    Genomic GenBank:BX784023 (1) 231254 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IU72 (1) 585 aa
    Sequence Information (all 19)
    ORTHOLOGY for alas2 ( Chr: 8 )
    CITATIONS (87)