ZFIN ID: ZDB-GENE-001229-1
Gene Name: aminolevulinate, delta-, synthase 2
Gene Symbol: alas2
Sequence Ontology ID : SO:0000704

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Previous Names: alas-e, sau (1), cb1063 (1), sauternes (1), si:dkey-24f17.4, si:dkey-24f17none

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(Including Attributions)
Location: Chr: 8 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 26 figures from 18 publications
Directly Submitted Expression Data: 2 figures (3 images) from Thisse et al., 2001 [cb1063]
  5 figures (5 images) from Thisse et al., 2004 [MGC:65747]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Hatching:Long-pec (48.0h-60.0h)
  blood, erythroid progenitor cell, hematopoietic stem cell, intermediate cell mass of mesoderm (all 9) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
tb223 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty121 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-alas2 (1), MO2-alas2 (1)
    PHENOTYPE
    Data: 6 figures from 4 publications
    Observed in: anatomical system, basophilic erythroblast, blood, erythroblast (all 9) expand
    DISEASE ASSOCIATED WITH alas2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    erythropoietic protoporphyria Protoporphyria, erythropoietic, X-linked 300752
    X-linked sideroblastic anemia Anemia, sideroblastic, 1 300751
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hemoglobin metabolic process (more)
    Cellular Component mitochondrial inner membrane (more)
    Molecular Function 5-aminolevulinate synthase activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001917 (1)
  • InterPro:IPR004839 (1)
  • InterPro:IPR010961 (1)
  • InterPro:IPR015118 (1)
  • InterPro:IPR015421 (1)
  • InterPro:IPR015422 (1)
  • InterPro:IPR015424 (1)
  • PROSITE:PS00599 (1)
  • Pfam:PF00155 (1)
  • Pfam:PF09029 (1)
  • EC:2.3.1.37 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA alas2-001 (1) 2544
    ncRNA alas2-002 (1) 618
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIES
    Ab1-alas2 (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM alas2 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    alas2Contained in: [BAC] DKEY-24F17 (1) (order this), DKEY-163F12 (1) (order this)
    alas2Encodes: [EST] cb1063 (1) (order this)
    [cDNA] MGC:65747 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131682 (1) 2540bp
    Genomic GenBank:BX784023 (1) 231254bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IU72 (1) 585aa
    Sequence Clusters UniGene:8180 (1)
    Sequence Information (all 19)
    OTHER alas2 GENE PAGES
  • Gene:64607 (1)
  • VEGA:OTTDARG00000020550 (1)
  • Ensembl(GRCz10):ENSDARG00000038643 (1)
  • ORTHOLOGY for alas2 (Chr: 8)
    CITATIONS (68)