Gene

cyp19a1b

ID

ZDB-GENE-001103-4

Name

cytochrome P450, family 19, subfamily A, polypeptide 1b

Symbol

cyp19a1b Nomenclature History

Previous Names

CYP19a2 (1)
cyp19b (2)
AroB (2)
aromatase B (1)
brain aromatase (1)
P450aromB (1)
zgc:92614

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have heme binding activity; iron ion binding activity; and oxidoreductase activity. Involved in several processes, including response to estradiol; response to estrogen; and response to steroid hormone. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; ovarian disease (multiple); prostate disease (multiple); and urethral obstruction. Is expressed in several structures, including brain; cranial nerve; gonad; head; and radial glial cell. Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

67 figures from 30 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cyp19a1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
aromatase excess syndrome	Alliance	Aromatase excess syndrome	139300
		Aromatase deficiency	613546

Associated With cyp19a1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017972	Cytochrome P450, conserved site
Family	IPR001128	Cytochrome P450
Family	IPR002401	Cytochrome P450, E-class, group I
Homologous_superfamily	IPR036396	Cytochrome P450 superfamily

Domain Details Per Protein

Protein	Length	Cytochrome P450	Cytochrome P450, conserved site	Cytochrome P450, E-class, group I	Cytochrome P450 superfamily
UniProtKB:A0A890BQ19 InterPro
UniProtKB:Q5U870 InterPro	511
UniProtKB:A0A8M9PGW6 InterPro	513

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
pseudogenic transcript	cyp19a1b-001 (1) Ensembl	Havana	4167 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
AB1-cyp19a1b	polyclonal	cyp19a1b		Rabbit			11

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations