ZFIN ID: ZDB-GENE-001103-4
Gene Name: cytochrome P450, family 19, subfamily A, polypeptide 1b
Gene Symbol: cyp19a1b
Sequence Ontology ID : SO:0000704

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Previous Names: CYP19a2 (1), cyp19b (2), AroB (2), aromatase B (1), brain aromatase (1), P450aromB (1), zgc:92614

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(Including Attributions)
Location: Chr: 25 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 62 figures from 25 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  anterior lateral line nerve, brain, caudal parvocellular preoptic nucleus, caudal periventricular hypothalamus (all 57) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa24593 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa37992 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • uc39 Small Deletion Unknown Frameshift, Premature Stop TALEN
    uc40 Small Deletion Unknown Frameshift, Premature Stop TALEN
    Targeting reagents: MO1-cyp19a1b (1), MO2-cyp19a1b (1), MO3-cyp19a1b (1), TALEN1-cyp19a1b (1)
    PHENOTYPE
    Data: 4 figures from Alharthy et al., 2017
    Observed in: caudal fin, eye, hatching, pericardium (all 8) expand
    DISEASE ASSOCIATED WITH cyp19a1b HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    aromatase excess syndrome Aromatase excess syndrome 139300
    Aromatase deficiency 613546
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to estradiol (more)
    Cellular Component integral component of membrane (more)
    Molecular Function heme binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001128 (1)
  • InterPro:IPR002401 (1)
  • InterPro:IPR017972 (1)
  • PROSITE:PS00086 (1)
  • Pfam:PF00067 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    pseudogenic transcript cyp19a1b-001 (1) 4167
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    AB1-cyp19a1b (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM cyp19a1b
    Tg(cyp19a1b:cyp19a1b-GFP), Tg(cyp19a1b:GFP)
    MARKER RELATIONSHIPS
    cyp19a1bContained in: [BAC] CH211-286K11 (1) (order this)
    cyp19a1bEncodes: [cDNA] MGC:92614 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131642 (1) 3809bp
    Genomic GenBank:AL954697 (1) 134798bp
    Select Tool
    Polypeptide UniProtKB:Q5U870 (1) 511aa
    Sequence Clusters UniGene:10461 (1)
    Sequence Information (all 30)
    OTHER cyp19a1b GENE PAGES
  • Alliance (1)
  • Gene:60640 (1)
  • VEGA:OTTDARG00000021147 (1)
  • Ensembl(GRCz10):ENSDARG00000098360 (1)
  • ORTHOLOGY for cyp19a1b (Chr: 25)
    CITATIONS (166)