Gene

cyp19a1b

ID
ZDB-GENE-001103-4
Name
cytochrome P450, family 19, subfamily A, polypeptide 1b
Symbol
cyp19a1b Nomenclature History
Previous Names
  • CYP19a2 (1)
  • cyp19b (2)
  • AroB (2)
  • aromatase B (1)
  • brain aromatase (1)
  • P450aromB (1)
  • zgc:92614
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have heme binding activity; iron ion binding activity; and oxidoreductase activity. Involved in several processes, including response to estradiol; response to estrogen; and response to steroid hormone. Predicted to localize to integral component of membrane. Is expressed in several structures, including brain; cranial nerve; gonad; head; and radial glial cell. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; ovarian disease (multiple); prostate disease (multiple); and urethral obstruction. Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
67 figures from 30 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cyp19a1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Aromatase deficiency 613546
Aromatase excess syndrome 139300
Associated With cyp19a1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017972 Cytochrome P450, conserved site
Family IPR001128 Cytochrome P450
Family IPR002401 Cytochrome P450, E-class, group I
Homologous_superfamily IPR036396 Cytochrome P450 superfamily
Domain Details Per Protein
Protein Length Cytochrome P450 Cytochrome P450, conserved site Cytochrome P450, E-class, group I Cytochrome P450 superfamily
UniProtKB:A0A890BQ19
UniProtKB:Q5U870 511
UniProtKB:A0A8M9PGW6 513
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
pseudogenic transcript cyp19a1b-001 (1) Havana 4167 nt
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
AB1-cyp19a1b polyclonal Rabbit
  • IHC
11
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations