ZFIN ID: ZDB-GENE-001103-4
Gene Name: cytochrome P450, family 19, subfamily A, polypeptide 1b
Gene Symbol: cyp19a1b    Nomenclature History

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Previous Names: CYP19a2 (1), cyp19b (2), AroB (2), aromatase B (1), brain aromatase (1), P450aromB (1), zgc:92614

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have heme binding activity; iron ion binding activity; and oxidoreductase activity. Involved in several processes, including response to estradiol; response to estrogen; and response to steroid hormone. Predicted to localize to integral component of membrane. Is expressed in several structures, including brain; cranial nerve; gonad; head; and radial glial cell. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; ovarian disease (multiple); prostate disease (multiple); and urethral obstruction. Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1).
Genome Resources: Alliance (1),  Gene:60640 (1),  Ensembl(GRCz11):ENSDARG00000098360 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa24593 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37991 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37992 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • uc39 Small Deletion Unknown Frameshift, Premature Stop TALEN
    uc40 Small Deletion Unknown Frameshift, Premature Stop TALEN
    zf1032 Small Deletion Exon 4 Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cyp19a1b N/A 1
    MO2-cyp19a1b N/A 1
    MO3-cyp19a1b N/A 1
    MO4-cyp19a1b N/A 2
    TALEN1-cyp19a1b 1
    TALEN2-cyp19a1b 1
    DISEASE ASSOCIATED WITH cyp19a1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    aromatase excess syndrome Alliance Aromatase excess syndrome 139300
    Aromatase deficiency 613546
    DISEASE ASSOCIATED WITH cyp19a1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to estradiol (more)
    Cellular Component integral component of membrane (more)
    Molecular Function heme binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    pseudogenic transcript cyp19a1b-001 (1)    Ensembl 4167
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    AB1-cyp19a1b polyclonal Rabbit 9
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyp19a1b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(cyp19a1b:cyp19a1b-GFP) cyp19a1b cyp19a1bGFP Danio rerio 1 28
    MARKER RELATIONSHIPS
    cyp19a1b Contained in: [BAC] CH211-286K11 (1)
    cyp19a1b Encodes: [cDNA] MGC:92614 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131642 (1) 3809 nt
    Genomic GenBank:AL954697 (1) 134798 nt
    Select Tool
    Polypeptide UniProtKB:Q5U870 (1) 511 aa
    Sequence Information (all 29)
    ORTHOLOGY for cyp19a1b ( Chr: 25 )
    CITATIONS (250)