ZFIN ID: ZDB-GENE-001103-4
Gene Name: cytochrome P450, family 19, subfamily A, polypeptide 1b
Gene Symbol: cyp19a1b
Previous Names: CYP19a2 (1), cyp19b (2), AroB (2), aromatase B (1), brain aromatase (1), P450aromB, zgc:92614
Location: Chr: 25 Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 58 figures from 23 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  anterior lateral line nerve, brain, caudal parvocellular preoptic nucleus, caudal periventricular hypothalamus (all 57) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Mutagen Suppliers
sa24593 Point Mutation ENU
Targeting reagents: MO1-cyp19a1b (1), MO2-cyp19a1b (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH cyp19a1b HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
Aromatase excess syndrome 139300
Aromatase deficiency 613546
GENE ONTOLOGY
Ontology GO Term
Biological Process response to estradiol (more)
Cellular Component integral component of membrane (more)
Molecular Function heme binding (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001128 (1)
  • InterPro:IPR002401 (1)
  • InterPro:IPR017972 (1)
  • PROSITE:PS00086 (1)
  • Pfam:PF00067 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    pseudogenic transcript cyp19a1b-001 (1) 4167
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    AB1-cyp19a1b (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM cyp19a1b
    Tg(cyp19a1b:cyp19a1b-GFP), Tg(cyp19a1b:GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    cyp19a1bContained in: [BAC] CH211-286K11 (1) (order this)
    cyp19a1bEncodes: [cDNA] MGC:92614 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131642 (1) 3809bp
    Genomic GenBank:AL954697 (1) 134798bp
    Select Tool
    Polypeptide UniProtKB:Q5U870 (1) 511aa
    Sequence Clusters UniGene:10461 (1)
    Sequence Information (all 22)
    OTHER cyp19a1b GENE PAGES
  • Gene:60640 (1)
  • VEGA:OTTDARG00000021147 (1)
  • Ensembl(GRCz10):ENSDARG00000098360 (1)
  • ORTHOLOGY for cyp19a1b (Chr: 25)
    Species Symbol Chromosome Accession # Evidence
    Human CYP19A1 15
  • Gene:1588
  • OMIM:107910
  • HGNC:2594
  • Amino acid sequence comparison (4)
    Conserved genome location (synteny) (2)
    Mouse Cyp19a1 9
  • MGI:88587
  • Gene:13075
  • Amino acid sequence comparison (3)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (116)