Gene
hoxa9a
- ID
- ZDB-GENE-000823-1
- Name
- homeobox A9a
- Symbol
- hoxa9a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in embryonic skeletal system morphogenesis; regionalization; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within DNA-templated transcription and regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including margin; mesoderm; musculature system; nervous system; and tail bud. Orthologous to human HOXA9 (homeobox A9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 31 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6898223 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028009Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa18147 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-hoxa9a | N/A | (2) |
| MO2-hoxa9a | N/A | Sundaramoorthi et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Abd-B homeobox transcription factor | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein HXA9/HXB9/HXC9 | Homeodomain | Homeodomain, metazoa | Hox9, N-terminal activation domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9PWL6 | InterPro | 250 | |||||||
| UniProtKB:B2GSB0 | InterPro | 250 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cr382300.2-201
(1)
|
Ensembl | 498 nt | ||
| mRNA |
hoxa9a-201
(1)
|
Ensembl | 926 nt | ||
| mRNA |
hoxa9a-202
(1)
|
Ensembl | 1,752 nt |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(drl:hoxa9a-2A-GFP) |
| 1 | Wei et al., 2024 | ||
| Tg(drl:hoxa9a-6x-MYC,cryaa:Venus-GFP) |
| 1 | Wang et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-25E11 | ZFIN Curated Data | |
| Encodes | EST | fd07f09 | ||
| Encodes | EST | IMAGE:6898223 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:110505 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192530 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131532 (1) | 1770 nt | ||
| Genomic | GenBank:CR382300 (1) | 202006 nt | ||
| Polypeptide | UniProtKB:B2GSB0 (1) | 250 aa |
- Ishizaka, M., Maeno, A., Nakazawa, H., Fujii, R., Oikawa, S., Tani, T., Kanno, H., Koita, R., Kawamura, A. (2024) The functional roles of zebrafish HoxA- and HoxD-related clusters in the pectoral fin development. Scientific Reports. 14:2360223602
- Wei, X., Wang, W., Yin, Q., Li, H., Ahmed, A., Ullah, R., Li, W., Jing, L. (2024) In Vivo Chemical Screening in Zebrafish Embryos Identified FDA-Approved Drugs That Induce Differentiation of Acute Myeloid Leukemia Cells. International Journal of Molecular Sciences. 25(14):
- Sundaramoorthi, H., Fallatah, W., Mary, J., Jagadeeswaran, P. (2023) Discovery of seven hox genes in zebrafish thrombopoiesis. Blood cells, molecules & diseases. 104:102796102796
- Wang, H., He, J., Han, X., Wu, X., Ye, X., Lv, W., Zu, Y. (2023) hoxa1a-Null Zebrafish as a Model for Studying HOXA1-Associated Heart Malformation in Bosley-Salih-Alorainy Syndrome. Biology. 12(7):
- Albert, L., Nagpal, J., Steinchen, W., Zhang, L., Werel, L., Djokovic, N., Ruzic, D., Hoffarth, M., Xu, J., Kaspareit, J., Abendroth, F., Royant, A., Bange, G., Nikolic, K., Ryu, S., Dou, Y., Essen, L.O., Vázquez, O. (2022) Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. ACS central science. 8:57-66
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Wang, W., Li, H., Huang, M., Wang, X., Li, W., Qian, X., Jing, L. (2022) Hoxa9/meis1-transgenic zebrafish develops acute myeloid leukaemia-like disease with rapid onset and high penetrance. Open Biology. 12:220172
- Franke, M., De la Calle-Mustienes, E., Neto, A., Almuedo-Castillo, M., Irastorza-Azcarate, I., Acemel, R.D., Tena, J.J., Santos-Pereira, J.M., Gómez-Skarmeta, J.L. (2021) CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression. Nature communications. 12:5415
- Mitchell, J.M., Sucharov, J., Pulvino, A.T., Brooks, E.P., Gillen, A.E., Nichols, J.T. (2021) The alx3 gene shapes the zebrafish neurocranium by regulating frontonasal neural crest cell differentiation timing. Development (Cambridge, England). 148(7):
- Mukaigasa, K., Sakuma, C., Yaginuma, H. (2021) The developmental hourglass model is applicable to the spinal cord based on single-cell transcriptomes and non-conserved cis-regulatory elements. Development, growth & differentiation. 63(7):372-391
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