Gene

ucp2

ID

ZDB-GENE-990708-8

Name

uncoupling protein 2

Symbol

ucp2 Nomenclature History

Previous Names

zUCP2 (1)
cb74 (1)

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to have oxidative phosphorylation uncoupler activity. Predicted to be involved in adaptive thermogenesis; mitochondrial transmembrane transport; and response to cold. Predicted to localize to integral component of membrane and mitochondrial inner membrane. Human ortholog(s) of this gene implicated in artery disease (multiple); diabetic neuropathy; end stage renal failure; non-alcoholic fatty liver disease; and obesity. Is expressed in several structures, including blood; brain; cardiovascular system; pleuroperitoneal region; and ventral mesoderm. Orthologous to human UCP2 (uncoupling protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb74 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ucp2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Obesity, susceptibility to, BMIQ4}	607447

Associated With ucp2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Homologous_superfamily	IPR023395	Mitochondrial carrier domain superfamily
Repeat	IPR018108	Mitochondrial substrate/solute carrier

Domain Details Per Protein

Protein	Length	Mitochondrial carrier domain superfamily	Mitochondrial substrate/solute carrier
UniProtKB:Q6P0I3 InterPro	310
UniProtKB:A0A8M3B6H4 InterPro	258
UniProtKB:Q9W720 InterPro	310

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ucp2-201 (1) Ensembl	Havana	1518 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ucp2-002 (1) Ensembl	Havana	789 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ucp2-003 (1) Ensembl	Havana	779 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ucp2-004 (1) Ensembl	Havana	757 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ucp2-005 (1) Ensembl	Havana	807 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations