PUBLICATION

Mitochondrial proton leak and the uncoupling protein 1 homologues

Authors
Stuart, J.A., Cadenas, S., Jekabsons, M.B., Roussel, D., and Brand, M.D.
ID
ZDB-PUB-010410-1
Date
2001
Source
Biochim. Biophys. Acta Bio-Energetics   1504(1): 144-158 (Review)
Registered Authors
Keywords
mitochondrion; proton conductance; basal metabolic rate; respiration; UCP1; UCP2; BMCP1; fatty acid; brown adipose tissue; thermogenesis; zebrafish; carp
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Animals, Genetically Modified
  • Basal Metabolism
  • Carrier Proteins/chemistry
  • Carrier Proteins/metabolism*
  • Diffusion
  • Humans
  • Intracellular Membranes/metabolism
  • Ion Channels
  • Membrane Proteins/chemistry
  • Membrane Proteins/metabolism*
  • Membrane Transport Proteins*
  • Mitochondria/metabolism*
  • Mitochondrial Proteins*
  • Models, Animal
  • Molecular Sequence Data
  • Proteins/metabolism
  • Protons*
  • RNA, Messenger/metabolism
  • Sequence Alignment
  • Sequence Homology
PubMed
11239491 Full text @ Biochim. Biophys. Acta Bio-Energetics
Abstract
Mitochondrial proton leak is the largest single contributor to the standard metabolic rate (SMR) of a rat, accounting for about 20% of SMR. Yet the mechanisms by which proton leak occurs are incompletely understood. The available evidence suggests that both phospholipids and proteins in the mitochondrial inner membrane are important determinants of proton conductance. The uncoupling protein 1 homologues (e.g. UCP2, UCP3) may play a role in mediating proton leak, but it is unlikely they account for all of the observed proton conductance. Experimental data regarding the functions of these proteins include important ambiguities and contradictions which must be addressed before their function can be confirmed. The physiological role of the proton leak, and of the uncoupling protein 1 homologues, remains similarly unclear.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping