Gene

tle3b

ID

ZDB-GENE-990415-85

Name

TLE family member 3, transcriptional corepressor b

Symbol

tle3b Nomenclature History

Previous Names

fi28a02
fj62f10
grg3 (1)
gro1
gro3
wu:fi28a02
wu:fj62f10
zfgro1

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have repressing transcription factor binding activity and transcription corepressor activity. Involved in myeloid cell differentiation. Predicted to localize to nucleus and transcription factor complex. Is expressed in several structures, including axis; head; immature eye; intestine; and mesoderm. Orthologous to human TLE3 (TLE family member 3, transcriptional corepressor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu137 (18 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tle3b Human Ortholog

No data available

Associated With tle3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Domain	IPR005617	Groucho/TLE, N-terminal Q-rich domain
Family	IPR009146	Groucho/transducin-like enhancer
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	Groucho/TLE, N-terminal Q-rich domain	Groucho/transducin-like enhancer	WD40 repeat	WD40 repeat, conserved site	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A8M3B166 InterPro	781
UniProtKB:A0A8M3AU86 InterPro	770
UniProtKB:A0A8M3AU69 InterPro	782
UniProtKB:A0A8M2BG40 InterPro	770
UniProtKB:A0A8M3AU78 InterPro	760
UniProtKB:O13168 InterPro	771
UniProtKB:A0A8M3AU75 InterPro	780
UniProtKB:A0A8M3B444 InterPro	760
UniProtKB:A0A8M3BB05 InterPro	761
UniProtKB:A0A8M3BB02 InterPro	781
UniProtKB:A0A8M3B441 InterPro	771
UniProtKB:A0A8M3AU81 InterPro	781
UniProtKB:A0A8M3B175 InterPro	759

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tle3b-201 (1) Ensembl	Ensembl	4,239 nt	Select Tool
mRNA	tle3b-203 (1) Ensembl	Ensembl	598 nt	Select Tool
mRNA	tle3b-205 (1) Ensembl	Ensembl	5,168 nt	Select Tool ZFIN BLAST
mRNA	tle3b-206 (1) Ensembl	Ensembl	5,123 nt	Select Tool ZFIN BLAST
ncRNA	tle3b-002 (1) Ensembl	Ensembl	529 nt	Select Tool
ncRNA	tle3b-004 (1) Ensembl	Ensembl	593 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations