ZFIN is now using GRCz12tu for Genomic Data
Gene
pam
- ID
- ZDB-GENE-090313-384
- Name
- peptidylglycine alpha-amidating monooxygenase
- Symbol
- pam Nomenclature History
- Previous Names
-
- si:dkeyp-35f12.2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables peptidylglycine monooxygenase activity. Acts upstream of or within ciliary transition zone assembly and microvillus assembly. Predicted to be located in transport vesicle membrane. Predicted to be active in extracellular region. Is expressed in floor plate; gut; otic vesicle; and ventricular system. Orthologous to human PAM (peptidylglycine alpha-amidating monooxygenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Kumar et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Kumar et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000323 | Copper type II, ascorbate-dependent monooxygenase, N-terminal |
| Domain | IPR024548 | Copper type II ascorbate-dependent monooxygenase, C-terminal |
| Family | IPR000720 | Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase |
| Homologous_superfamily | IPR008977 | PHM/PNGase F domain superfamily |
| Homologous_superfamily | IPR011042 | Six-bladed beta-propeller, TolB-like |
| Homologous_superfamily | IPR014784 | Copper type II, ascorbate-dependent monooxygenase-like, C-terminal |
| Homologous_superfamily | IPR036939 | Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily |
| Repeat | IPR001258 | NHL repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Copper type II ascorbate-dependent monooxygenase, C-terminal | Copper type II, ascorbate-dependent monooxygenase-like, C-terminal | Copper type II, ascorbate-dependent monooxygenase, N-terminal | Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily | NHL repeat | Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase | PHM/PNGase F domain superfamily | Six-bladed beta-propeller, TolB-like |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z0R0 | InterPro | 779 | ||||||||
| UniProtKB:A0A8M2B2D2 | InterPro | 1010 | ||||||||
| UniProtKB:A0A8M3B606 | InterPro | 909 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers