Gene
spint2
- ID
- ZDB-GENE-061013-323
- Name
- serine peptidase inhibitor, Kunitz type, 2
- Symbol
- spint2 Nomenclature History
- Previous Names
-
- fb52h04
- fe24a06
- wu:fb52h04
- wu:fe24a06
- zgc:153795
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; ectoderm; oral epithelium; peridermal cell; and polster. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 3. Orthologous to human SPINT2 (serine peptidase inhibitor, Kunitz type 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 8 figures from Hatzold et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital secretory sodium diarrhea 3 | Alliance | Diarrhea 3, secretory sodium, congenital, syndromic | 270420 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Pancreatic trypsin inhibitor Kunitz domain | Pancreatic trypsin inhibitor Kunitz domain superfamily | Proteinase inhibitor I2, Kunitz, conserved site | Seven cysteines, N-terminal |
|---|---|---|---|---|---|
|
UniProtKB:F1QEV7
|
431 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
spint2-201
(1)
|
Ensembl | 2,024 nt | ||
| mRNA |
spint2-202
(1)
|
Ensembl | 836 nt |
Interactions and Pathways
No data available
Plasmids
No data available