Gene

txnrd2.2

ID

ZDB-GENE-040914-66

Name

thioredoxin reductase 2, tandem duplicate 2

Symbol

txnrd2.2 Nomenclature History

Previous Names

im:7135991 (1)
si:ch1073-179p4.3

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have thioredoxin-disulfide reductase activity. Predicted to be involved in cell redox homeostasis. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human TXNRD2 (thioredoxin reductase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7135991 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With txnrd2.2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Glucocorticoid deficiency 5	617825

Associated With txnrd2.2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR012999	Pyridine nucleotide-disulphide oxidoreductase, class I, active site
Domain	IPR004099	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
Domain	IPR023753	FAD/NAD(P)-binding domain
Family	IPR001100	Pyridine nucleotide-disulphide oxidoreductase, class I
Family	IPR006338	Thioredoxin/glutathione reductase selenoprotein
Family	IPR046952	Glutathione reductase/thioredoxin reductase-like
Homologous_superfamily	IPR016156	FAD/NAD-linked reductase, dimerisation domain superfamily
Homologous_superfamily	IPR036188	FAD/NAD(P)-binding domain superfamily