Gene
myo6a
- ID
- ZDB-GENE-040819-2
- Name
- myosin VIa
- Symbol
- myo6a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within blood vessel morphogenesis; inner ear development; and response to auditory stimulus. Predicted to be located in microvillus and ruffle membrane. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; endocytic vesicle; and ruffle. Is expressed in dorsal aorta; neural tube; posterior cardinal vein; and somite. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 22 | Alliance | Deafness, autosomal dominant 22 | 606346 |
| autosomal dominant nonsyndromic deafness 22 | Alliance | Deafness, autosomal dominant 22, with hypertrophic cardiomyopathy | 606346 |
| autosomal recessive nonsyndromic deafness 37 | Alliance | Deafness, autosomal recessive 37 | 607821 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001609 | Myosin head, motor domain-like |
| Domain | IPR004009 | Myosin, N-terminal, SH3-like |
| Domain | IPR032412 | Myosin VI, cargo binding domain |
| Domain | IPR036114 | Class VI myosin, motor domain |
| Domain | IPR049016 | Myosin VI, lever arm |
| Homologous_superfamily | IPR008989 | Myosin S1 fragment, N-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Class VI myosin, motor domain | Kinesin motor domain superfamily | Myosin head, motor domain-like | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin VI, cargo binding domain | Myosin VI, lever arm | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B757 | InterPro | 1278 | ||||||||
| UniProtKB:A0A8M9PBP4 | InterPro | 1150 | ||||||||
| UniProtKB:F1Q6Q6 | InterPro | 1253 | ||||||||
| UniProtKB:A0A8M9P2J2 | InterPro | 1153 | ||||||||
| UniProtKB:A0A8M3AL94 | InterPro | 1281 | ||||||||
| UniProtKB:A0A8M3AVX0 | InterPro | 1268 | ||||||||
| UniProtKB:A0A8M9PH95 | InterPro | 1288 | ||||||||
| UniProtKB:A0A8M3ASY2 | InterPro | 1256 | ||||||||
| UniProtKB:A0AB32T8A7 | InterPro | 1275 | ||||||||
| UniProtKB:A0AB32T911 | InterPro | 1265 | ||||||||
| UniProtKB:A0AB32TDX7 | InterPro | 1263 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available