Gene

hdac8

ID

ZDB-GENE-040426-2772

Name

histone deacetylase 8

Symbol

hdac8 Nomenclature History

Previous Names

wu:fd19a02
zgc:66196 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have histone deacetylase activity. Predicted to be involved in histone H3 deacetylation; histone H4 deacetylation; and positive regulation of transcription by RNA polymerase II. Predicted to localize to histone deacetylase complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7144626 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hdac8 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Cornelia de Lange syndrome 5	Alliance	Cornelia de Lange syndrome 5	300882

Associated With hdac8 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Cornelia de Lange syndrome	AB + MO2-hdac8	standard conditions	Bottai et al., 2018
Cornelia de Lange syndrome	AB + MO3-hdac8	standard conditions	Bottai et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011613	GH15-like domain
Domain	IPR023801	Histone deacetylase domain
Domain	IPR045583	Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain
Family	IPR000286	Histone deacetylase family
Family	IPR003084	Histone deacetylase
Family	IPR008734	Phosphorylase kinase alpha/beta subunit
Homologous_superfamily	IPR008928	Six-hairpin glycosidase superfamily
Homologous_superfamily	IPR012341	Six-hairpin glycosidase-like superfamily
Homologous_superfamily	IPR023696	Ureohydrolase domain superfamily
Homologous_superfamily	IPR037138	Histone deacetylase domain superfamily

Domain Details Per Protein

Protein	Length	GH15-like domain	Histone deacetylase	Histone deacetylase domain	Histone deacetylase domain superfamily	Histone deacetylase family	Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain	Phosphorylase kinase alpha/beta subunit	Six-hairpin glycosidase-like superfamily	Six-hairpin glycosidase superfamily	Ureohydrolase domain superfamily
UniProtKB:Q7SXM0 InterPro	378
UniProtKB:A0A8M2BE34 InterPro	311
UniProtKB:A0A286YAZ5 InterPro	1232
UniProtKB:E7F4R5 InterPro	1219

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	hdac8-205 (1) Ensembl	Havana	566 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	hdac8-201 (1) Ensembl	Havana	1935 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	hdac8-203 (1) Ensembl	Havana	725 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	hdac8-002 (1) Ensembl	Havana	475 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	hdac8-004 (1) Ensembl	Havana	528 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-hdac8	polyclonal	hdac8	IgG	Rabbit	WB	Santa Cruz Biotechnology, Inc.	4

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations