Gene

apc

ID

ZDB-GENE-031112-7

Name

APC regulator of WNT signaling pathway

Symbol

apc Nomenclature History

Previous Names

cb965 (1)
im:7150932
im:7152872

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable several functions, including beta-catenin binding activity; gamma-catenin binding activity; and microtubule binding activity. Involved in somitogenesis. Acts upstream of with a positive effect on digestive tract development. Acts upstream of or within several processes, including digestive system development; regionalization; and sensory system development. Predicted to be located in several cellular components, including centrosome; kinetochore; and lateral plasma membrane. Predicted to be part of beta-catenin destruction complex and catenin complex. Predicted to colocalize with cytoplasmic microtubule. Is expressed in hypochord; nervous system; neural tube; and trigeminal placode. Used to study familial adenomatous polyposis. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial adenomatous polyposis 1; gastrointestinal system cancer (multiple); hereditary desmoid disease; and reproductive organ cancer (multiple). Orthologous to human APC (APC regulator of WNT signaling pathway).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

21 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb965 (9 images)
IMAGE:7150932 (8 images)
IMAGE:7152872 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 67 figures from 27 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With apc Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
colorectal cancer	Alliance	Colorectal cancer, somatic	114500
familial adenomatous polyposis 1	Alliance	Adenoma, periampullary, somatic	175100
familial adenomatous polyposis 1	Alliance	Adenomatous polyposis coli	175100
familial adenomatous polyposis 1	Alliance	Brain tumor-polyposis syndrome 2	175100
familial adenomatous polyposis 1	Alliance	Gardner syndrome	175100
hepatocellular carcinoma	Alliance	Hepatoblastoma, somatic	114550
hereditary desmoid disease	Alliance	Desmoid disease, hereditary	135290
stomach cancer	Alliance	Gastric cancer, somatic	613659
		Gastric adenocarcinoma and proximal polyposis of the stomach	619182

Associated With apc Via Experimental Models

Human Disease	Fish	Conditions	Citations
familial adenomatous polyposis	apc^hu745/+; ia28Tg	standard conditions	Peron et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR009232	EB-1 binding
Domain	IPR009234	Adenomatous polyposis coli protein basic domain
Domain	IPR032038	Adenomatous polyposis coli, N-terminal dimerisation domain
Family	IPR026818	Adenomatous polyposis coli (APC) family
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR026831	Adenomatous polyposis coli protein
Homologous_superfamily	IPR036149	APC, N-terminal coiled-coil domain superfamily
Repeat	IPR000225	Armadillo
Repeat	IPR009223	Adenomatous polyposis coli protein repeat
Repeat	IPR009224	SAMP
Repeat	IPR009240	Adenomatous polyposis coli protein, 15 residue repeat
Repeat	IPR041257	Adenomatous polyposis coli (APC) repeat