Gene

hdr

ID

ZDB-GENE-030826-5

Name

hematopoietic death receptor

Symbol

hdr Nomenclature History

Previous Names

zgc:103531
ZH-DR

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. Localizes to plasma membrane. Human ortholog(s) of this gene implicated in cervical cancer; head and neck squamous cell carcinoma; hematologic cancer (multiple); and urinary system cancer (multiple). Is expressed in axis; hematopoietic system; mesoderm; and notochord. Orthologous to several human genes including TNFRSF10A (TNF receptor superfamily member 10a) and TNFRSF10B (TNF receptor superfamily member 10b).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

20 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:103531 (12 images)
eu245 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hdr Human Ortholog

No data available

Associated With hdr Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000488	Death domain
Domain	IPR001368	TNFR/NGFR cysteine-rich region
Domain	IPR034024	Tumor necrosis factor receptor 10, N-terminal
Domain	IPR034029	Tumour necrosis factor receptor 10A/B, death domain
Family	IPR052491	Tumor necrosis factor receptor superfamily member 10
Homologous_superfamily	IPR011029	Death-like domain superfamily