Gene
birc5b
- ID
- ZDB-GENE-030826-2
- Name
- baculoviral IAP repeat containing 5b
- Symbol
- birc5b Nomenclature History
- Previous Names
-
- survivin 2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including circulatory system development; nuclear chromosome segregation; and regulation of apoptotic process. Predicted to be located in chromosome, centromeric region and spindle. Is expressed in several structures, including axial blood vessel; caudal vein plexus; intermediate cell mass of mesoderm; nervous system; and unfertilized egg. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Orthologous to human BIRC5 (baculoviral IAP repeat containing 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Baculoviral IAP repeat-containing | BIR repeat |
|---|---|---|---|
|
UniProtKB:Q90WU8
|
128 | ||
|
UniProtKB:A0A8M9PSV1
|
102 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
birc5b-201
(1)
|
Ensembl | 598 nt | ||
| ncRNA |
birc5b-002
(1)
|
Ensembl | 612 nt | ||
| ncRNA |
birc5b-003
(1)
|
Ensembl | 525 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-birc5 | monoclonal | IgG | Rabbit |
|
Cell Signaling Technology, Inc.
|
3 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-104L7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:123152 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_145195 (1) | 489 nt | ||
| Genomic | GenBank:BX571968 (1) | 225376 nt | ||
| Polypeptide | UniProtKB:Q90WU8 (1) | 128 aa |
- Nair, S., Welch, E.L., Moravec, C.E., Trevena, R.L., Hansen, C.L., Pelegri, F. (2023) The midbody component Prc1-like is required for microtubule reorganization during cytokinesis and dorsal determinant segregation in the early zebrafish embryo. Development (Cambridge, England). 150(4)
- Saraswathy, V.M., Zhou, L., McAdow, A.R., Burris, B., Dogra, D., Reischauer, S., Mokalled, M.H. (2022) Myostatin is a negative regulator of adult neurogenesis after spinal cord injury in zebrafish. Cell Reports. 41:111705111705
- Moravec, C.E., Voit, G.C., Otterlee, J., Pelegri, F. (2021) Identification of maternal-effect genes in zebrafish using maternal crispants. Development (Cambridge, England). 148(19)
- Abrams, E.W., Fuentes, R., Marlow, F.L., Kobayashi, M., Zhang, H., Lu, S., Kapp, L., Joseph, S.R., Kugath, A., Gupta, T., Lemon, V., Runke, G., Amodeo, A.A., Vastenhouw, N.L., Mullins, M.C. (2020) Molecular genetics of maternally-controlled cell divisions. PLoS Genetics. 16:e1008652
- Lin, Y.C., Wu, C.Y., Hu, C.H., Pai, T.W., Chen, Y.R., Wang, W.D. (2020) Integrated Hypoxia Signaling and Oxidative Stress in Developmental Neurotoxicity of Benzo[a]Pyrene in Zebrafish Embryos. Antioxidants (Basel, Switzerland). 9(8)
- Frohnhöfer, H.G., Geiger-Rudolph, S., Pattky, M., Meixner, M., Huhn, C., Maischein, H.M., Geisler, R., Gehring, I., Maderspacher, F., Nüsslein-Volhard, C., Irion, U. (2016) Spermidine, but not spermine, is essential for pigment pattern formation in zebrafish. Biology Open. 5(6):736-44
- Tzung, K.W., Goto, R., Saju, J.M., Sreenivasan, R., Saito, T., Arai, K., Yamaha, E., Hossain, M.S., Calvert, M.E., Orbán, L. (2015) Early Depletion of Primordial Germ Cells in Zebrafish Promotes Testis Formation. Stem Cell Reports. 4(1):61-73
- Aboualaiwi, W.A., Muntean, B.S., Ratnam, S., Joe, B., Liu, L., Booth, R.L., Rodriguez, I., Herbert, B.S., Bacallao, R.L., Fruttiger, M., Mak, T.W., Zhou, J., and Nauli, S.M. (2014) Survivin-Induced Abnormal Ploidy Contributes to Cystic Kidney and Aneurysm Formation. Circulation. 129(6):660-72
- Lin, T.Y., Chou, C.F., Chung, H.Y., Chiang, C.Y., Li, C.H., Wu, J.L., Lin, H.J., Pai, T.W., Hu, C.H., Tzou, W.S. (2014) Hypoxia-Inducible Factor 2 Alpha Is Essential for Hepatic Outgrowth and Functions via the Regulation of leg1 Transcription in the Zebrafish Embryo. PLoS One. 9:e101980
- Jung, I.H., Leem, G.L., Jung, D.E., Kim, M.H., Kim, E.Y., Kim, S.H., Park, H.C., and Park, S.W. (2013) Glioma is formed by active Akt1 alone and promoted by active Rac1 in transgenic zebrafish. Neuro-Oncology. 15(3):290-304
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