Gene
dusp6
- ID
- ZDB-GENE-030613-1
- Name
- dual specificity phosphatase 6
- Symbol
- dusp6 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Exhibits phosphoprotein phosphatase activity. Involved in several processes, including negative regulation of cardiac muscle tissue regeneration; regulation of endodermal cell fate specification; and regulation of signal transduction. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Is expressed in several structures, including brain; fin; germ ring; gonad; and head. Orthologous to human DUSP6 (dual specificity phosphatase 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 64 figures from 43 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 19 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 19 with or without anosmia | 615269 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000340 | Dual specificity phosphatase, catalytic domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR001763 | Rhodanese-like domain |
| Domain | IPR020422 | Dual specificity protein phosphatase domain |
| Family | IPR008343 | Mitogen-activated protein (MAP) kinase phosphatase |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
| Homologous_superfamily | IPR036873 | Rhodanese-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Dual specificity phosphatase, catalytic domain | Dual specificity protein phosphatase domain | Mitogen-activated protein (MAP) kinase phosphatase | Protein-tyrosine phosphatase-like | Rhodanese-like domain | Rhodanese-like domain superfamily | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7T2L8
|
382 |
Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-dusp6 | monoclonal | IgG1 , k | Mouse |
|
Sigma-Aldrich
|
4 |
Plasmids