Gene

dusp6

ID

ZDB-GENE-030613-1

Name

dual specificity phosphatase 6

Symbol

dusp6 Nomenclature History

Previous Names

etID14116.25 (1)
Mkp3 (2)
wu:fd99d09 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Exhibits phosphoprotein phosphatase activity. Involved in several processes, including negative regulation of cardiac muscle tissue regeneration; regulation of endodermal cell fate specification; and regulation of signal transduction. Predicted to localize to cytosol. Is expressed in several structures, including brain; fin; germ ring; head; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Orthologous to human DUSP6 (dual specificity phosphatase 6).

Genome Resources

Note

None

Expression

All Expression Data

63 figures from 42 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dusp6 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypogonadotropic hypogonadism 19 with or without anosmia	Alliance	Hypogonadotropic hypogonadism 19 with or without anosmia	615269

Associated With dusp6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000387	Tyrosine specific protein phosphatases domain
Domain	IPR001763	Rhodanese-like domain
Domain	IPR020422	Dual specificity protein phosphatase domain
Family	IPR008343	Mitogen-activated protein (MAP) kinase phosphatase
Homologous_superfamily	IPR029021	Protein-tyrosine phosphatase-like
Homologous_superfamily	IPR036873	Rhodanese-like domain superfamily

Domain Details Per Protein

Protein	Length	Dual specificity protein phosphatase domain	Mitogen-activated protein (MAP) kinase phosphatase	Protein-tyrosine phosphatase-like	Rhodanese-like domain	Rhodanese-like domain superfamily	Tyrosine specific protein phosphatases domain
UniProtKB:Q7T2L8 InterPro	382

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	dusp6-201 (1) Ensembl	2918 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	dusp6-002 (1) Ensembl	750 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

SignaFish

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-dusp6	monoclonal	dusp6	IgG1 , k	Mouse	IHC WB	Sigma-Aldrich	4

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Gene Tree: Ensembl

Citations