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ZIRC
ZFIN ID: ZDB-GENE-030613-1
Gene Name: dual specificity phosphatase 6
Gene Symbol: dusp6    Nomenclature History

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Previous Names: etID14116.25 (1), Mkp3 (2), wu:fd99d09 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Exhibits phosphoprotein phosphatase activity. Involved in several processes, including negative regulation of cardiac muscle tissue regeneration; regulation of endodermal cell fate specification; and regulation of signal transduction. Predicted to localize to the cytosol. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Is expressed in several structures, including brain; fin; germ ring; gonad; and heart. Orthologous to human DUSP6 (dual specificity phosphatase 6).
Genome Resources: Alliance (1),  Gene:353314 (1),  Ensembl(GRCz11):ENSDARG00000070914 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
pt30a Small Deletion Exon 1 Frameshift, Premature Stop TALEN
pt30b Small Deletion Exon 1 Frameshift, Premature Stop TALEN
pt30c Small Deletion Exon 1 Frameshift, Premature Stop TALEN
pt30d Insertion Exon 1 Frameshift, Premature Stop TALEN
sa24648 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39479 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • um239 Indel Unknown Unknown CRISPR
    um286 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-dusp6 1
    CRISPR2-dusp6 1
    MO1-dusp6 N/A 1
    MO2-dusp6 N/A 1
    MO3-dusp6 N/A 1
    TALEN1-dusp6 1
    DISEASE ASSOCIATED WITH dusp6 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hypogonadotropic hypogonadism 19 with or without anosmia Alliance Hypogonadotropic hypogonadism 19 with or without anosmia 615269
    DISEASE ASSOCIATED WITH dusp6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein dephosphorylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function phosphoprotein phosphatase activity (more)
    GO Terms (all 18)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dusp6-201 (1)    Ensembl 2918
    ncRNA dusp6-002 (1) 750
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-dusp6 monoclonal IgG1 , k Mouse IHC, WB Sigma-Aldrich
    4
    CONSTRUCTS WITH SEQUENCES FROM dusp6
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(dusp6:Cre-ERT2,myl7:ECFP) dusp6myl7 CreECFPERT2 Danio rerio 1 3
    Tg(dusp6:d2EGFP) dusp6 d2EGFP Danio rerio 5 34
    Tg(dusp6:GAL4-ERT2-VP16,myl7:ECFP) dusp6myl7 ECFPERT2GAL4VP16 Danio rerio 1 2
    Tg(dusp6:GFP-MA) dusp6 GFP Danio rerio 1 7
    Tg(dusp6:MA-GFP) dusp6 GFPMA Danio rerio 1 2
    Tg(hsp70l:dusp6) hsp70l dusp6 Danio rerio 1 2
    Tg(UAS:NLS-Tomato-2A-dusp6) UAS 2Adusp6NLSTomato Danio rerio 1 1
    MARKER RELATIONSHIPS
    dusp6 Contained in: [BAC] DKEY-164B12 (1) (order this)
    dusp6 Encodes: [EST] fd99d09 (1)
    [cDNA] MGC:73342 (1) (order this), MGC:77006 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_194380 (1) 2942 bp
    Genomic GenBank:CR405685 (1) 116349 bp
    Select Tool
    Polypeptide UniProtKB:Q7T2L8 (1) 382 aa
    Sequence Clusters UniGene:16301 (1)
    Sequence Information (all 18)
    ORTHOLOGY for dusp6 ( Chr: 25 )
    CITATIONS (108)