ZFIN ID: ZDB-GENE-030613-1 |
Gene Name: | dual specificity phosphatase 6 | ||||||
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Gene Symbol: | dusp6 Nomenclature History | ||||||
Previous Names: | etID14116.25 (1), Mkp3 (2), wu:fd99d09 (1) | ||||||
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Gene Type: | protein_coding_gene | ||||||
Location: | Chr: 25 Mapping Details/Browsers | ||||||
Description: | Exhibits phosphoprotein phosphatase activity. Involved in several processes, including negative regulation of cardiac muscle tissue regeneration; regulation of endodermal cell fate specification; and regulation of signal transduction. Predicted to localize to the cytosol. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Is expressed in several structures, including brain; fin; germ ring; gonad; and heart. Orthologous to human DUSP6 (dual specificity phosphatase 6). | ||||||
Genome Resources: | Alliance (1), Gene:353314 (1), Ensembl(GRCz11):ENSDARG00000070914 (1) |
Allele | Type | Localization | Consequence | Mutagen | Suppliers |
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pt30a | Small Deletion | Exon 1 | Frameshift, Premature Stop | TALEN | |
pt30b | Small Deletion | Exon 1 | Frameshift, Premature Stop | TALEN | |
pt30c | Small Deletion | Exon 1 | Frameshift, Premature Stop | TALEN | |
pt30d | Insertion | Exon 1 | Frameshift, Premature Stop | TALEN | |
sa24648 | Point Mutation | Unknown | Premature Stop | ENU |
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sa39479 | Point Mutation | Unknown | Premature Stop | ENU |
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um239 | Indel | Unknown | Unknown | CRISPR | |
um286 | Small Deletion | Unknown | Unknown | CRISPR |
Data: | 5 figures from 2 publications |
Observed in: |
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
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hypogonadotropic hypogonadism 19 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 19 with or without anosmia | 615269 |
Ontology | GO Term |
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Biological Process | protein dephosphorylation (more) |
Cellular Component | cytoplasm (more) |
Molecular Function | phosphoprotein phosphatase activity (more) |
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Type | Name | Length (nt) | Analysis | |
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mRNA |
dusp6-201
(1)
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2918 |
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ncRNA | dusp6-002 (1) | 750 |
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Browsers: UCSC, NCBI, Ensembl, ZFIN |
Name | Type | Isotype | Host Organism | Assay | Source | Publications |
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Ab1-dusp6 | monoclonal | IgG1 , k | Mouse | IHC, WB |
Sigma-Aldrich
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4 |
Addgene:pGL3-Dusp6_2KBpromoter |
Addgene:pISceI Dusp6:D2EGFP |
Addgene:pISceI Dusp6:memGFP |
Addgene:p3E-Dusp6DM_S159/197A |
Addgene:pmTol-InsUAS-6MTnlstdTomato2A-Dusp6DM-CC |
Construct | Regulatory Regions | Coding Sequences | Species | Tg Lines | Publications |
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Tg(dusp6:Cre-ERT2,myl7:ECFP) | dusp6, myl7 | Cre, ECFP, ERT2 | Danio rerio | 1 | 3 |
Tg(dusp6:d2EGFP) | dusp6 | d2EGFP | Danio rerio | 5 | 34 |
Tg(dusp6:GAL4-ERT2-VP16,myl7:ECFP) | dusp6, myl7 | ECFP, ERT2, GAL4, VP16 | Danio rerio | 1 | 2 |
Tg(dusp6:GFP-MA) | dusp6 | GFP | Danio rerio | 1 | 7 |
Tg(dusp6:MA-GFP) | dusp6 | GFP, MA | Danio rerio | 1 | 2 |
Tg(hsp70l:dusp6) | hsp70l | dusp6 | Danio rerio | 1 | 2 |
Tg(UAS:NLS-Tomato-2A-dusp6) | UAS | 2A, dusp6, NLS, Tomato | Danio rerio | 1 | 1 |
dusp6 Contained in: | [BAC] DKEY-164B12 (1) (order this) |
dusp6 Encodes: |
[EST]
fd99d09 (1)
[cDNA] MGC:73342 (1) (order this), MGC:77006 (1) (order this) |
Type | Accession # | Length (bp/aa) | Analysis |
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RNA | RefSeq:NM_194380 (1) | 2942 bp |
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Genomic | GenBank:CR405685 (1) | 116349 bp | |
Polypeptide | UniProtKB:Q7T2L8 (1) | 382 aa |
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Sequence Clusters | UniGene:16301 (1) |