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ZIRC
ZFIN ID: ZDB-GENE-030613-1
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Gene Name: dual specificity phosphatase 6
Gene Symbol: dusp6
Sequence Ontology ID : SO:0001217

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Previous Names: etID14116.25 (1), Mkp3 (2), wu:fd99d09 (1)

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(Including Attributions)
Location: Chr: 25 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits phosphoprotein phosphatase activity. Involved in several processes, including negative regulation of cardiac muscle tissue regeneration; regulation of endodermal cell fate specification; and  ...
GENE EXPRESSION
All Expression Data: 59 figures from 39 publications
Wild-type Stages, Structures: Cleavage:64-cell (2.0h-2.25h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
pt30a Small Deletion Exon 1 Frameshift, Premature Stop TALEN
pt30b Small Deletion Exon 1 Frameshift, Premature Stop TALEN
pt30c Small Deletion Exon 1 Frameshift, Premature Stop TALEN
pt30d Insertion Exon 1 Frameshift, Premature Stop TALEN
sa24648 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa39479 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • um239 Indel Unknown Unknown CRISPR
    um286 Small Deletion Unknown Unknown CRISPR
    Targeting reagents:
    PHENOTYPE
    Data: 5 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH dusp6 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    hypogonadotropic hypogonadism 19 with or without anosmia Hypogonadotropic hypogonadism 19 with or without anosmia 615269
    DISEASE ASSOCIATED WITH dusp6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein dephosphorylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function phosphoprotein phosphatase activity (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000340 (1)
  • InterPro:IPR000387 (1)
  • InterPro:IPR001763 (1)
  • InterPro:IPR008343 (1)
  • InterPro:IPR020422 (1)
  • InterPro:IPR029021 (1)
  • InterPro:IPR036873 (1)
  • PROSITE:PS50054 (1)
  • PROSITE:PS50056 (1)
  • PROSITE:PS50206 (1)
  • Pfam:PF00581 (1)
  • Pfam:PF00782 (1)
  • EC:3.1.3.48 (1)
    • TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA dusp6-002 (1) 750
    Select Tool
    mRNA dusp6-201 (1) 2918
    Select Tool
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM dusp6
    MARKER RELATIONSHIPS
    dusp6 Contained in: [BAC] DKEY-164B12 (1) (order this)
    dusp6 Encodes: [EST] fd99d09 (1)
    [cDNA] MGC:73342 (1) (order this), MGC:77006 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_194380 (1) 2942 bp
    Select Tool
    Genomic GenBank:CR405685 (1) 116349 bp
    Select Tool
    Polypeptide UniProtKB:Q7T2L8 (1) 382 aa
    Select Tool
    Sequence Clusters UniGene:16301 (1)
    Sequence Information (all 18)
    OTHER dusp6 GENE PAGES
  • Alliance (1)
  • Gene:353314 (1)
  • VEGA:OTTDARG00000021197 (1)
  • Ensembl(GRCz11):ENSDARG00000070914 (1)
    • ORTHOLOGY for dusp6 ( Chr: 25 )
    CITATIONS (109)