Gene

tg

ID

ZDB-GENE-030519-1

Name

thyroglobulin

Symbol

tg Nomenclature History

Previous Names

cb717 (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Localizes to extracellular region. Human ortholog(s) of this gene implicated in Graves' disease; autoimmune thyroiditis; and goiter. Is expressed in pharyngeal arch; thyroid follicle; and thyroid primordium. Orthologous to human TG (thyroglobulin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

50 figures from 25 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb717 (16 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Song et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tg Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
thyroid dyshormonogenesis 3	Alliance	Thyroid dyshormonogenesis 3	274700
		{Autoimmune thyroid disease, susceptibility to, 3}	608175

Associated With tg Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000716	Thyroglobulin type-1
Domain	IPR002018	Carboxylesterase, type B
Domain	IPR011641	Tyrosine-protein kinase ephrin type A/B receptor-like
Family	IPR052001	MHC Class II Gamma Chain/Thyroglobulin
Homologous_superfamily	IPR029058	Alpha/Beta hydrolase fold
Homologous_superfamily	IPR036857	Thyroglobulin type-1 superfamily