ZFIN ID: ZDB-GENE-030519-1
Gene Name: thyroglobulin
Gene Symbol: tg    Nomenclature History

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Previous Name: cb717 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Localizes to the extracellular region. Human ortholog(s) of this gene implicated in Graves' disease; autoimmune thyroiditis; and goiter. Is expressed in pharyngeal arch; thyroid follicle; and thyroid primordium. Orthologous to human TG (thyroglobulin).
Genome Resources: Alliance (1),  Gene:567631 (1),  Ensembl(GRCz11):ENSDARG00000020084 (2)
GENE EXPRESSION
All Expression Data: 32 figures from 14 publications
Directly Submitted Expression Data: 3 figures (16 images) from Thisse et al., 2001 [cb717]
Wild-type Stages, Structures: Pharyngula:Prim-15 (30.0h-36.0h) to Adult (90d-730d, breeding adult)
 
PHENOTYPE No data available
DISEASE ASSOCIATED WITH tg HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Thyroid dyshormonogenesis 3 274700
{Autoimmune thyroid disease, susceptibility to, 3} 608175
DISEASE ASSOCIATED WITH tg VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Cellular Component extracellular region (more)
GO Terms (all 1)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR000716 Thyroglobulin type-1
Domain IPR002018 Carboxylesterase, type B
Domain IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
Homologous_superfamily IPR036857 Thyroglobulin type-1 superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA tg-201 (1)    Ensembl 8356
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-tg polyclonal Rabbit IHC, WB Dako North America, Inc.
4
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM tg
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(tg:EGFP) tg EGFP Danio rerio 1 1
tg(tg:egfp,myl7:egfp) myl7tg EGFP Danio rerio 1 1
Tg(tg:Hsa.BRAF_V600E-Tomato) tg Tomato Danio rerioHomo sapiens 1 1
Tg(tg:MA-mCherry) tg mCherry Danio rerio 1 8
Tg(tg:mCherry) tg mCherry Danio rerio 1 1
Tg(tg:NLS-EGFP) tg EGFPNLS Danio rerio 1 1
Tg(tg:Tomato) tg Tomato Danio rerio 2 1
Tg(tg:Venus,NTR) tg NTRVenus Danio rerio 1 12
MARKER RELATIONSHIPS
tg Contained in: [BAC] DKEY-97I18 (1) (order this)
tg Encodes: [EST] cb717 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001329865 (1)
Genomic GenBank:CR855311 (1) 161379 nt
Select Tool
Polypeptide UniProtKB:F1QFR0 (1) 2741 aa
Sequence Information (all 13)
ORTHOLOGY for tg ( Chr: 16 )
CITATIONS (99)