Gene

tg

ID
ZDB-GENE-030519-1
Name
thyroglobulin
Symbol
tg Nomenclature History
Previous Names
  • cb717 (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have hormone activity. Predicted to be involved in thyroid hormone generation. Localizes to extracellular region. Is expressed in pharyngeal arch; thyroid follicle; and thyroid primordium. Human ortholog(s) of this gene implicated in Graves' disease; autoimmune thyroiditis; and goiter. Orthologous to human TG (thyroglobulin).
Genome Resources
Note
None
Expression
All Expression Data
33 figures from 15 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tg Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Thyroid dyshormonogenesis 3 274700
{Autoimmune thyroid disease, susceptibility to, 3} 608175
Associated With tg Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000716 Thyroglobulin type-1
Domain IPR002018 Carboxylesterase, type B
Domain IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
Homologous_superfamily IPR036857 Thyroglobulin type-1 superfamily
Domain Details Per Protein
Protein Length Alpha/Beta hydrolase fold Carboxylesterase, type B Thyroglobulin type-1 Thyroglobulin type-1 superfamily Tyrosine-protein kinase ephrin type A/B receptor-like
UniProtKB:A0A193GP06 2733
UniProtKB:F1QFR0 2741
UniProtKB:Q2VA53 336
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-tg polyclonal Rabbit
  • IHC
  • WB
Dako North America, Inc.
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations