Gene

pik3c2a

ID

ZDB-GENE-030328-39

Name

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha

Symbol

pik3c2a Nomenclature History

Previous Names

sb:cb156
si:dkey-24l11.7 (1)
wu:fc02a04

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in angiogenesis. Predicted to localize to cytoplasm; phosphatidylinositol 3-kinase complex; and plasma membrane. Is expressed in several structures, including axis; heart tube; nervous system; notochord; and pectoral fin musculature. Orthologous to human PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2001

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb156 (23 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pik3c2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Oculoskeletodental syndrome	618440

Associated With pik3c2a Via Experimental Models

Human Disease	Fish	Conditions	Citations
cataract	pik3c2a^{sa10124/sa10124}	standard conditions	Gulluni et al., 2021
cataract	pik3c2a^{sa12328/sa12328}	standard conditions	Gulluni et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
Domain	IPR000008	C2 domain
Domain	IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
Domain	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain	IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain
Domain	IPR001683	Phox homology
Domain	IPR002420	C2 phosphatidylinositol 3-kinase-type domain
Domain	IPR042133	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain
Family	IPR015433	Phosphatidylinositol kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR036871	PX domain superfamily
Homologous_superfamily	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Homologous_superfamily	IPR042236	Phosphoinositide 3-kinase, accessory (PIK) domain superfamily

Domain Details Per Protein

Protein	Length	Armadillo-type fold	C2 domain	C2 domain superfamily	C2 phosphatidylinositol 3-kinase-type domain	Phosphatidylinositol 3-/4-kinase, catalytic domain	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily	Phosphatidylinositol 3/4-kinase, conserved site	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain	Phosphatidylinositol kinase	Phosphoinositide 3-kinase, accessory (PIK) domain	Phosphoinositide 3-kinase, accessory (PIK) domain superfamily	Phox homology	Protein kinase-like domain superfamily	PX domain superfamily	Ubiquitin-like domain superfamily
UniProtKB:A0A8M2B5U1 InterPro	1691
UniProtKB:A0A8M9PYW4 InterPro	1195
UniProtKB:A0A8M9PQU0 InterPro	1691
UniProtKB:A0A8M9Q547 InterPro	1189
UniProtKB:A0A2R8QSP1 InterPro	1685
UniProtKB:F6NMW9 InterPro	1685

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pik3c2a-202 (1) Ensembl	Havana	6219 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-PI3K-C2alpha	polyclonal	pik3c2a		Rabbit	IHC WB	Proteintech	1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations