Gene

pik3c2a

ID
ZDB-GENE-030328-39
Name
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Symbol
pik3c2a Nomenclature History
Previous Names
  • sb:cb156
  • si:dkey-24l11.7 (1)
  • wu:fc02a04
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in angiogenesis. Predicted to localize to cytoplasm; phosphatidylinositol 3-kinase complex; and plasma membrane. Is expressed in several structures, including axis; heart tube; nervous system; notochord; and pectoral fin musculature. Orthologous to human PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. 6 from Lai et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pik3c2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Oculoskeletodental syndrome 618440
Associated With pik3c2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
Domain IPR000008 C2 domain
Domain IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
Domain IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
Domain IPR001683 Phox homologous domain
Domain IPR002420 Phosphatidylinositol 3-kinase, C2 domain
Domain IPR042133 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain
Family IPR015433 Phosphatidylinositol kinase
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR036871 PX domain superfamily
Homologous_superfamily IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Homologous_superfamily IPR042236 Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
Domain Details Per Protein
Protein Length Armadillo-type fold C2 domain C2 domain superfamily Phosphatidylinositol 3-/4-kinase, catalytic domain Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily Phosphatidylinositol 3/4-kinase, conserved site Phosphatidylinositol 3-kinase, C2 domain Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain Phosphatidylinositol kinase Phosphoinositide 3-kinase, accessory (PIK) domain Phosphoinositide 3-kinase, accessory (PIK) domain superfamily Phox homologous domain Protein kinase-like domain superfamily PX domain superfamily Ubiquitin-like domain superfamily
UniProtKB:Q1L913 1725
UniProtKB:F6NMW9 1685
UniProtKB:A0A2R8Q031 1715
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations