Gene

pik3c2a

ID

ZDB-GENE-030328-39

Name

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha

Symbol

pik3c2a Nomenclature History

Previous Names

sb:cb156
si:dkey-24l11.7 (1)
wu:fc02a04

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Acts upstream of or within angiogenesis. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including axis; heart tube; nervous system; notochord; and pectoral fin musculature. Used to study cataract. Orthologous to human PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2001

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb156 (23 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pik3c2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Oculoskeletodental syndrome	618440

Associated With pik3c2a Via Experimental Models

Human Disease	Fish	Conditions	Citations
cataract	pik3c2a^{sa10124/sa10124}	standard conditions	Gulluni et al., 2021
cataract	pik3c2a^{sa12328/sa12328}	standard conditions	Gulluni et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
Domain	IPR000008	C2 domain
Domain	IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
Domain	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain	IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain
Domain	IPR001683	Phox homology
Domain	IPR002420	C2 phosphatidylinositol 3-kinase-type domain
Domain	IPR042133	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain
Family	IPR015433	Phosphatidylinositol kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR036871	PX domain superfamily
Homologous_superfamily	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Homologous_superfamily	IPR042236	Phosphoinositide 3-kinase, accessory (PIK) domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M2B5U1	InterPro	1691
UniProtKB:A0A8M9PYW4	InterPro	1195
UniProtKB:A0A8M9PQU0	InterPro	1691
UniProtKB:A0A8M9Q547	InterPro	1189
UniProtKB:A0A2R8QSP1	InterPro	1685
UniProtKB:F6NMW9	InterPro	1685

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pik3c2a-201 (1) Ensembl	Ensembl	9,132 nt	Select Tool ZFIN BLAST
mRNA	pik3c2a-202 (1) Ensembl	Ensembl	6,219 nt	Select Tool ZFIN BLAST
mRNA	pik3c2a-203 (1) Ensembl	Ensembl	9,222 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-PI3K-C2alpha	polyclonal	pik3c2a		Rabbit	IHC WB	Proteintech	1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations