Gene
chia.4
- ID
- ZDB-GENE-030131-9279
- Name
- chitinase, acidic.4
- Symbol
- chia.4 Nomenclature History
- Previous Names
-
- chia4 (1)
- wu:fa55g10
- zgc:63792
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable chitin binding activity and endochitinase activity. Predicted to be involved in chitin catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Located in cytoplasm and membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to several human genes including CHIT1 (chitinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63792 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la014332Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa24287 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37660 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR001579 | Glycosyl hydrolase family 18, active site |
| Domain | IPR001223 | Glycoside hydrolase family 18, catalytic domain |
| Domain | IPR002557 | Chitin binding domain |
| Domain | IPR011583 | Chitinase II/V-like, catalytic domain |
| Family | IPR050314 | Glycosyl Hydrolase Family 18 |
| Homologous_superfamily | IPR017853 | Glycoside hydrolase superfamily |
| Homologous_superfamily | IPR029070 | Chitinase insertion domain superfamily |
| Homologous_superfamily | IPR036508 | Chitin binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Chitinase II/V-like, catalytic domain | Chitinase insertion domain superfamily | Chitin binding domain | Chitin binding domain superfamily | Glycoside hydrolase family 18, catalytic domain | Glycoside hydrolase superfamily | Glycosyl Hydrolase Family 18 | Glycosyl hydrolase family 18, active site |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PSY6 | InterPro | 475 | ||||||||
| UniProtKB:Q7SYA8 | InterPro | 475 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
chia.4-201
(1)
|
Ensembl | 2,223 nt | ||
| ncRNA |
chia.4-002
(1)
|
Ensembl | 775 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-390P7 | ZFIN Curated Data | |
| Encodes | EST | fa55g10 | ||
| Encodes | cDNA | MGC:63792 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200446 (1) | 2060 nt | ||
| Genomic | GenBank:CU234171 (2) | 83292 nt | ||
| Polypeptide | UniProtKB:A0A8M9PSY6 (1) | 475 aa |
No data available
- Xu, Y., Tian, J., Kang, Q., Yuan, H., Liu, C., Li, Z., Liu, J., Li, M. (2022) Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish. Frontiers in endocrinology. 13:864631
- Ayobahan, S.U., Eilebrecht, S., Baumann, L., Teigeler, M., Hollert, H., Kalkhof, S., Eilebrecht, E., Schäfers, C. (2020) Detection of biomarkers to differentiate endocrine disruption from hepatotoxicity in zebrafish (Danio rerio) using proteomics. Chemosphere. 240:124970
- Yang, Y., Dong, F., Liu, X., Xu, J., Wu, X., Zheng, Y. (2020) Thifluzamide induces the toxic effects on zebrafish (Danio rerio) via inhibition of succinate dehydrogenase (SDH). Environmental pollution (Barking, Essex : 1987). 265:115031
- Ayobahan, S.U., Eilebrecht, E., Kotthoff, M., Baumann, L., Eilebrecht, S., Teigeler, M., Hollert, H., Kalkhof, S., Schäfers, C. (2019) A combined FSTRA-shotgun proteomics approach to identify molecular changes in zebrafish upon chemical exposure. Scientific Reports. 9:6599
- Vargas, A., Randazzo, B., Riolo, P., Truzzi, C., Gioacchini, G., Giorgini, E., Loreto, N., Ruschioni, S., Zarantoniello, M., Antonucci, M., Polverini, S., Cardinaletti, G., Sabbatini, S., Tulli, F., Olivotto, I. (2018) Rearing Zebrafish on Black Soldier Fly (Hermetia illucens): Biometric, Histological, Spectroscopic, Biochemical, and Molecular Implications. Zebrafish. 15(4):404-419
- Zarantoniello, M., Bruni, L., Randazzo, B., Vargas, A., Gioacchini, G., Truzzi, C., Annibaldi, A., Riolo, P., Parisi, G., Cardinaletti, G., Tulli, F., Olivotto, I. (2018) Partial Dietary Inclusion of Hermetia illucens (Black Soldier Fly) Full-Fat Prepupae in Zebrafish Feed: Biometric, Histological, Biochemical, and Molecular Implications. Zebrafish. 15(5):519-532
- Choksi, S.P., Babu, D., Lau, D., Yu, X., Roy, S. (2014) Systematic discovery of novel ciliary genes through functional genomics in the zebrafish. Development (Cambridge, England). 141:3410-9
- Koch, B.E., Stougaard, J., and Spaink, H.P. (2014) Spatial and temporal expression patterns of chitinase genes in developing zebrafish embryos. Gene expression patterns : GEP. 14(2):69-77
- Hussain, M., and Wilson J.B. (2013) New Paralogues and Revised Time Line in the Expansion of the Vertebrate GH18 Family. Journal of molecular evolution. 76(4):240-260
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
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