Gene

arhgef9b

ID

ZDB-GENE-030131-7745

Name

Cdc42 guanine nucleotide exchange factor (GEF) 9b

Symbol

arhgef9b Nomenclature History

Previous Names

arhgef9
wu:fj33b10

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have guanyl-nucleotide exchange factor activity. Involved in filopodium assembly and sprouting angiogenesis. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 8. Is expressed in caudal artery; caudal vein plexus; dorsal aorta; and intersegmental vessel. Orthologous to human ARHGEF9 (Cdc42 guanine nucleotide exchange factor 9).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Wakayama et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arhgef9b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental and epileptic encephalopathy 8	Alliance	Developmental and epileptic encephalopathy 8	300607

Associated With arhgef9b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR001452	SH3 domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR035728	Rho guanine nucleotide exchange factor 9, SH3 domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily

Domain Details Per Protein

Protein	Length	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	PH-like domain superfamily	Pleckstrin homology domain	Rho guanine nucleotide exchange factor 9, SH3 domain	SH3 domain	SH3-like domain superfamily
UniProtKB:F1Q628 InterPro	514
UniProtKB:A0A8M9PZ81 InterPro	520
UniProtKB:A0A8M9QB31 InterPro	573
UniProtKB:A0A8M9QKL8 InterPro	521
UniProtKB:A0A8M9QP60 InterPro	538
UniProtKB:A0A8M9QB25 InterPro	568
UniProtKB:A0A8M9QGF0 InterPro	540