ZFIN is now using GRCz12tu for Genomic Data
Gene
kif11
- ID
- ZDB-GENE-020426-1
- Name
- kinesin family member 11
- Symbol
- kif11 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable plus-end-directed microtubule motor activity. Acts upstream of or within neurogenesis; regulation of cell cycle; and vasculature development. Predicted to be located in spindle pole. Predicted to be active in mitotic spindle; nucleus; and spindle microtubule. Is expressed in several structures, including blood island; cardiovascular system; nervous system; pleuroperitoneal region; and radial glial cell. Used to study hereditary lymphedema and microcephaly with or without chorioretinopathy, lymphedema, or mental retardation. Human ortholog(s) of this gene implicated in microcephaly with or without chorioretinopathy, lymphedema, or mental retardation. Orthologous to human KIF11 (kinesin family member 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| microcephaly with or without chorioretinopathy, lymphedema, or mental retardation | Alliance | Microcephaly with or without chorioretinopathy, lymphedema, or impaired intellectual development | 152950 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019821 | Kinesin motor domain, conserved site |
| Domain | IPR001752 | Kinesin motor domain |
| Domain | IPR025901 | Kinesin-associated microtubule-binding domain |
| Domain | IPR047241 | Kinesin-like protein KIF11-like, kinesin motor domain |
| Family | IPR047149 | Kinesin-like protein KIF11-like |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Kinesin-associated microtubule-binding domain | Kinesin-like protein KIF11-like | Kinesin-like protein KIF11-like, kinesin motor domain | Kinesin motor domain | Kinesin motor domain, conserved site | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9P8S1 | InterPro | 1012 | |||||||
| UniProtKB:A0A8M9P014 | InterPro | 1061 | |||||||
| UniProtKB:F1QK82 | InterPro | 1062 | |||||||
| UniProtKB:A0AB32T3F3 | InterPro | 1012 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers