Gene
skic2
- ID
- ZDB-GENE-010430-5
- Name
- SKI2 subunit of superkiller complex
- Symbol
- skic2 Nomenclature History
- Previous Names
-
- skiv2l
- fb70b07
- wu:fb70b07
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable RNA helicase activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay. Predicted to act upstream of or within RNA catabolic process. Predicted to be part of Ski complex. Human ortholog(s) of this gene implicated in trichohepatoenteric syndrome 2. Orthologous to human SKIC2 (SKI2 subunit of superkiller complex).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| trichohepatoenteric syndrome 2 | Alliance | Trichohepatoenteric syndrome 2 | 614602 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR011545 | DEAD/DEAH box helicase domain |
| Domain | IPR012961 | ATP-dependent RNA helicase Ski2/MTR4, C-terminal |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR025696 | Exosome RNA helicase MTR4-like, beta-barrel domain |
| Domain | IPR040801 | Ski2, N-terminal domain |
| Domain | IPR048392 | Exosome RNA helicase MTR4-like, stalk |
| Family | IPR016438 | ATP-dependent RNA helicase SKI2-like |
| Family | IPR050699 | RNA/DNA Helicase |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | ATP-dependent RNA helicase SKI2-like | ATP-dependent RNA helicase Ski2/MTR4, C-terminal | DEAD/DEAH box helicase domain | Exosome RNA helicase MTR4-like, beta-barrel domain | Exosome RNA helicase MTR4-like, stalk | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | RNA/DNA Helicase | Ski2, N-terminal domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1LWQ1
|
1230 | ||||||||||
|
UniProtKB:F1R881
|
1249 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
skiv2l-201
(1)
|
Ensembl | 4,191 nt | ||
| mRNA |
skiv2l-203
(1)
|
Ensembl | 8,216 nt | ||
| ncRNA |
ottdart00000045245
(1)
|
Ensembl | 789 nt |
Interactions and Pathways
No data available
Plasmids
No data available