ZFIN Lab: Laboratory of Environmental Toxicology

ZFIN ID: ZDB-LAB-170208-9

ZFIN ID: ZDB-LAB-170208-9

Laboratory of Environmental Toxicology

PI/Director:	Wu, Kusheng
Contact Person:	Wu, Kusheng
Email:	kswu@stu.edu.cn
URL:	http://www.med.stu.edu.cn
Address:	Laboratory of Environmental Toxicology, Department of Preventive Medicine, Shantou University Medical College No.22, Xinling Rd. Shantou 515041, Guangdong, China
Country:	China
Phone:	86-754-88900445
Fax:	86-754-88557562
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

We are interested in health effects of POPs/PTS based on zebrafish model. Now We have evaluated reproductive toxicity and neurotoxicity of PBDEs on zebrafish.

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Shi, X., Wu, K., Liu, C., Cao, K., Zhang, Q., Wu, W., Luo, C., Huang, W. (2024) Preliminary investigation into the impact of BPA on osteoblast activity and bone development: In vitro and in vivo models. Environmental pollution (Barking, Essex : 1987). 347:123731

Zhang, Q., Luo, C., Li, Z., Huang, W., Zheng, S., Liu, C., Shi, X., Ma, Y., Ni, Q., Tan, W., Peng, J., Chen, Y., Wu, W., Li, J., Wu, K. (2024) Astaxanthin activates the Nrf2/Keap1/HO-1 pathway to inhibit oxidative stress and ferroptosis, reducing triphenyl phosphate (TPhP)-induced neurodevelopmental toxicity. Ecotoxicology and environmental safety. 271:115960115960

Zhang, Q., Wu, R., Zheng, S., Luo, C., Huang, W., Shi, X., Wu, K. (2023) Exposure of male adult zebrafish (Danio rerio) to triphenyl phosphate (TPhP) induces eye development disorders and disrupts neurotransmitter system-mediated abnormal locomotor behavior in larval offspring. Journal of hazardous materials. 465:133332133332

Zheng, S., Zhang, Q., Shi, X., Luo, C., Chen, J., Zhang, W., Wu, K., Tang, S. (2023) Developmental hazards of 2,2',4,4'-tetrabromodiphenyl ether induced endoplasmic reticulum stress on early life stages of zebrafish (Danio rerio). Ecotoxicology and environmental safety. 267:115615115615

Huang, W., Shi, X., Zhang, Q., Chen, Y., Zheng, S., Wu, W., Luo, C., Wu, K. (2023) Transgenerational effects of BDE-47 to zebrafish based on histomorphometry and toxicogenomic analyses. Chemosphere. 344:140401140401

Huang, W., Wu, T., Wu, R., Peng, J., Zhang, Q., Shi, X., Wu, K. (2023) Fish to learn: insights into the effects of environmental chemicals on eye development and visual function in zebrafish. Environmental science and pollution research international. 30(29):73018-73030

Huang, W., Shi, X., Chen, Y., Zhang, Q., Peng, J., Zheng, S., Wu, K. (2023) Comparative pharyngeal cartilage developmental toxicity of bisphenol A, bisphenol S and bisphenol AF to zebrafish (Danio rerio) larvae: A combination of morphometry and global transcriptome analyses. The Science of the total environment. 868:161702

Zhang, Q., Zheng, S., Shi, X., Luo, C., Huang, W., Lin, H., Peng, J., Tan, W., Wu, K. (2023) Neurodevelopmental toxicity of organophosphate flame retardant triphenyl phosphate (TPhP) on zebrafish (Danio rerio) at different life stages. Environment International. 172:107745107745

Shi, X., Wu, R., Wang, X., Huang, W., Zheng, S., Zhang, Q., Peng, J., Tan, W., Wu, K. (2022) Effects of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) on reproductive and endocrine function in female zebrafish (Danio rerio). Ecotoxicology and environmental safety. 248:114326114326

Zheng, S., Zhang, Q., Wu, R., Shi, X., Peng, J., Tan, W., Huang, W., Wu, K., Liu, C. (2022) Behavioral changes and transcriptomic effects at embryonic and post-embryonic stages reveal the toxic effects of 2,2',4,4'-tetrabromodiphenyl ether on neurodevelopment in zebrafish (Danio rerio). Ecotoxicology and environmental safety. 248:114310114310

Wang, X., Shi, X., Zheng, S., Zhang, Q., Peng, J., Tan, W., Wu, K. (2022) Perfluorooctane sulfonic acid (PFOS) exposures interfere with behaviors and transcription of genes on nervous and muscle system in zebrafish embryos. The Science of the total environment. 848:157816

Huang, W., Xiao, J., Shi, X., Zheng, S., Li, H., Liu, C., Wu, K. (2022) Effects of di-(2-ethylhexyl) phthalate (DEHP) on behavior and dopamine signaling in zebrafish (Danio rerio). Environmental Toxicology and Pharmacology. 93:103885

Huang, W., Wang, X., Zheng, S., Wu, R., Liu, C., Wu, K. (2021) Effect of bisphenol A on craniofacial cartilage development in zebrafish (Danio rerio) embryos: A morphological study. Ecotoxicology and environmental safety. 212:111991

Bao, M., Zheng, S., Liu, C., Huang, W., Xiao, J., Wu, K. (2020) Perfluorooctane sulfonate exposure alters sexual behaviors and transcriptions of genes in hypothalamic-pituitary-gonadal-liver axis of male zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 267:115585

Huang, W., Zheng, S., Xiao, J., Liu, C., Du, T., Wu, K. (2020) Parental exposure to bisphenol A affects pharyngeal cartilage development and causes global transcriptomic changes in zebrafish (Danio rerio) offspring. Chemosphere. 249:126537

Bao, M., Huang, W., Au, W.W., Zheng, S., Liu, C., Huang, Y., Wu, K. (2019) Exposure to perfluorooctane sulfonate based on circadian rhythm changes the fecundity and expression of certain genes on the hypothalamic-pituitary-gonadal-liver axis of female zebrafish. Toxicology and applied pharmacology. 381:114715

Zheng, S., Liu, C., Huang, Y., Bao, M., Huang, Y., Wu, K. (2017) Effects of 2,2',4,4'-tetrabromodiphenyl ether on neurobehavior and memory change and bcl-2, c-fos, grin1b and lingo1b gene expression in male zebrafish (Danio rerio). Toxicology and applied pharmacology. 333:10-16