ZFIN Person: Wu, Kusheng

ZFIN ID: ZDB-PERS-170208-15

ZFIN ID: ZDB-PERS-170208-15

Wu, Kusheng

Email:	kswu@stu.edu.cn
URL:	http://www.med.stu.edu.cn
Affiliation:	Laboratory of Environmental Toxicology
Address:	Laboratory of Environmental Toxicology, Department of Preventive Medicine, Shantou University Medical College No.22, Xinling Rd. Shantou 515041, Guangdong, China
Country:
Phone:	86-754-88900445
Fax:	86-754-88557562
ORCID ID:	0000-0001-5163-2524

BIOGRAPHY AND RESEARCH INTERESTS

Brief bios-ketch of Kusheng Wu, Ph.D., Professor of Environmental Medicine

Personal information
Name: Kusheng Wu
Gender: Male
Date of birth: Mar 1st 1972
Place of birth: Dongzhi, Anhui, China

Current Employment
Department of Preventive Medicine, Shantou University Medical College, Shantou, Guangdong, China 515041. kswu@stu.edu.cn
Tel: 86-754-88900445; Cell phone: 13211233942

Professional information (current)
Professor, Department of Preventive Medicine, Shantou University Medical College

Work experience (last 15 years)
2013~ Professor, Department of Preventive Medicine, Shantou University Medical College
2008~ Associate Professor, Department of Preventive Medicine, Shantou University Medical College
2004~ Lecturer, Department of Preventive Medicine, Shantou University Medical College
2001~ Secretary of Scientific Research and Teaching Facilities Management Council, Shantou University Medical College

Educational history
2007–2010 Ph.D., Shantou University Medical College
2004–2007 M.Sc., Shantou University Medical College
1990–1995 B.Sc., Central South University Hsiang-Ya Medical College

Teaching experience at STMC (last 15 years)
• 2013– Preventive Medicine, Medical Statistics, Toxicology, Professor
• 2008– Preventive Medicine, Medical Statistics, Toxicology, Associate Professor
• 2004– Evidence–based Medicine, Lecturer
• 2004– Epidemiology and Medical Statistics, Lecturer
• 2004– Preventive Medicine, Lecturer

Research at STMC (last 15 years)
• 2015–2018 Neurotoxicity effect of polybrominated diphenyl ethers (PBDEs) on experimental zebrafish (Danio rerio) and its mechanism, Supported by Natural Science Foundation of Guangdong Province (No. 2014A030313474)
• 2015–2016 Associations between polybrominated diphenyl ethers exposure and breast cancer risk, endocrinotherapy resistance and their mechanisms, supported by the National Natural Science Foundation of China (No. 81470152)
• 2013–2015 Reproductive toxicity effect of polybrominated diphenyl ethers (PBDEs) on experimental zebrafish (Danio rerio) and its mechanism, Supported by Medical Scientific Research Foundation of Guangdong Province, China (no. A2013392)
• 2012– DNA damage and effects on antioxidative enzymes in zebra fish (Danio rerio) induced by polybrominated diphenyl ethers (PBDEs), Supported by Science and Technology Innovating Project of Guangdong Province Office of Education (No. 2012KJCX0054)
• 2009–2012 Association between maternal exposure to perfluorooctanoic acid (PFOA) from electronic waste recycling and neonatal health outcomes, Supported by Science and Technology Planning Project of Guangdong Province, China (2009B030801308)
• 2007–2008 Polybrominated diphenyl ethers (PBDEs) exposure of lying-in women and newborns and its health impact in E-waste recycling areas, Supported by Medical Scientific Research Foundation of Guangdong Province, China (A2008432), and also Supported by Foundation of Shantou University medical college
• 2004–2007 Esophageal cancer and spatial factors by using Geographic Information System, Supported by Science and Technology Planning Project of Shantou City, China

Research interests

We are interested in the health effects of POPs/PTS based on zebrafish model. Now we have evaluated the reproductive toxicology and neurotoxicology of PBDEs on zebrafish and their mechanisms.

PUBLICATIONS

Zhang, Q., Luo, C., Li, Z., Huang, W., Zheng, S., Liu, C., Shi, X., Ma, Y., Ni, Q., Tan, W., Peng, J., Chen, Y., Wu, W., Li, J., Wu, K. (2024) Astaxanthin activates the Nrf2/Keap1/HO-1 pathway to inhibit oxidative stress and ferroptosis, reducing triphenyl phosphate (TPhP)-induced neurodevelopmental toxicity. Ecotoxicology and environmental safety. 271:115960115960

Zhang, Q., Wu, R., Zheng, S., Luo, C., Huang, W., Shi, X., Wu, K. (2023) Exposure of male adult zebrafish (Danio rerio) to triphenyl phosphate (TPhP) induces eye development disorders and disrupts neurotransmitter system-mediated abnormal locomotor behavior in larval offspring. Journal of hazardous materials. 465:133332133332

Zheng, S., Zhang, Q., Shi, X., Luo, C., Chen, J., Zhang, W., Wu, K., Tang, S. (2023) Developmental hazards of 2,2',4,4'-tetrabromodiphenyl ether induced endoplasmic reticulum stress on early life stages of zebrafish (Danio rerio). Ecotoxicology and environmental safety. 267:115615115615

Huang, W., Shi, X., Zhang, Q., Chen, Y., Zheng, S., Wu, W., Luo, C., Wu, K. (2023) Transgenerational effects of BDE-47 to zebrafish based on histomorphometry and toxicogenomic analyses. Chemosphere. 344:140401140401

Huang, W., Wu, T., Wu, R., Peng, J., Zhang, Q., Shi, X., Wu, K. (2023) Fish to learn: insights into the effects of environmental chemicals on eye development and visual function in zebrafish. Environmental science and pollution research international. 30(29):73018-73030

Huang, W., Shi, X., Chen, Y., Zhang, Q., Peng, J., Zheng, S., Wu, K. (2023) Comparative pharyngeal cartilage developmental toxicity of bisphenol A, bisphenol S and bisphenol AF to zebrafish (Danio rerio) larvae: A combination of morphometry and global transcriptome analyses. The Science of the total environment. 868:161702

Zhang, Q., Zheng, S., Shi, X., Luo, C., Huang, W., Lin, H., Peng, J., Tan, W., Wu, K. (2023) Neurodevelopmental toxicity of organophosphate flame retardant triphenyl phosphate (TPhP) on zebrafish (Danio rerio) at different life stages. Environment International. 172:107745107745

Shi, X., Wu, R., Wang, X., Huang, W., Zheng, S., Zhang, Q., Peng, J., Tan, W., Wu, K. (2022) Effects of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) on reproductive and endocrine function in female zebrafish (Danio rerio). Ecotoxicology and environmental safety. 248:114326114326

Zheng, S., Zhang, Q., Wu, R., Shi, X., Peng, J., Tan, W., Huang, W., Wu, K., Liu, C. (2022) Behavioral changes and transcriptomic effects at embryonic and post-embryonic stages reveal the toxic effects of 2,2',4,4'-tetrabromodiphenyl ether on neurodevelopment in zebrafish (Danio rerio). Ecotoxicology and environmental safety. 248:114310114310

Wang, X., Shi, X., Zheng, S., Zhang, Q., Peng, J., Tan, W., Wu, K. (2022) Perfluorooctane sulfonic acid (PFOS) exposures interfere with behaviors and transcription of genes on nervous and muscle system in zebrafish embryos. The Science of the total environment. 848:157816

Huang, W., Xiao, J., Shi, X., Zheng, S., Li, H., Liu, C., Wu, K. (2022) Effects of di-(2-ethylhexyl) phthalate (DEHP) on behavior and dopamine signaling in zebrafish (Danio rerio). Environmental Toxicology and Pharmacology. 93:103885

Huang, W., Wang, X., Zheng, S., Wu, R., Liu, C., Wu, K. (2021) Effect of bisphenol A on craniofacial cartilage development in zebrafish (Danio rerio) embryos: A morphological study. Ecotoxicology and environmental safety. 212:111991

Bao, M., Zheng, S., Liu, C., Huang, W., Xiao, J., Wu, K. (2020) Perfluorooctane sulfonate exposure alters sexual behaviors and transcriptions of genes in hypothalamic-pituitary-gonadal-liver axis of male zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 267:115585

Huang, W., Zheng, S., Xiao, J., Liu, C., Du, T., Wu, K. (2020) Parental exposure to bisphenol A affects pharyngeal cartilage development and causes global transcriptomic changes in zebrafish (Danio rerio) offspring. Chemosphere. 249:126537

Bao, M., Huang, W., Au, W.W., Zheng, S., Liu, C., Huang, Y., Wu, K. (2019) Exposure to perfluorooctane sulfonate based on circadian rhythm changes the fecundity and expression of certain genes on the hypothalamic-pituitary-gonadal-liver axis of female zebrafish. Toxicology and applied pharmacology. 381:114715

Zheng, S., Liu, C., Huang, Y., Bao, M., Huang, Y., Wu, K. (2017) Effects of 2,2',4,4'-tetrabromodiphenyl ether on neurobehavior and memory change and bcl-2, c-fos, grin1b and lingo1b gene expression in male zebrafish (Danio rerio). Toxicology and applied pharmacology. 333:10-16

NON-ZEBRAFISH PUBLICATIONS
1.He Y, Peng L, Huang Y, Peng X, Zheng S, Liu C, Wu K *. Association of breast adipose tissue levels of polychlorinated biphenyls and breast cancer development in women from Chaoshan, China. Environ Sci Pollut Res 2016, DOI 10.1007/s11356-016-8208-6.
2.He Y, Wang X, Wu K *. Evaluating Breast Cancer Risk under Exposure to Environmental Estrogen-Like Chemicals. Polish Journal of Environmental Studies 2016, 25(6): 2239-2249.
3.Zhang J, Huang Y, Wang X, Lin K, Wu K *. Environmental Polychlorinated Biphenyl Exposure and Breast Cancer Risk: A Meta-Analysis of Observational Studies. PLoS One 2015; 10: e0142513.
4.Peng L, Huang Y, Zhang J, Peng Y, Lin X, Wu K *, Huo X *. Cadmium exposure and the risk of breast cancer in Chaoshan population of southeast China. Environ Sci Pollut Res Int 2015. 22(24):19870-8
5.Peng L, Wang X, Huo X, Xu X, Lin K, Zhang J, Huang Y, Wu K *. Blood cadmium burden and the risk of nasopharyngeal carcinoma: a case-control study in Chinese Chaoshan population. Environ Sci Pollut Res Int, 2015, 22: 12323-31.
6.Huang Y, Zhu G, Peng L, Ni W, Wang X, Zhang J, Wu K *. Effect of 2,2′,4,4′-Tetrabromodiphenyl Ether (Bde-47) on Sexual Behaviors and Reproductive Function in Male Zebrafish (Danio Rerio). Ecotoxicology and Environmental Safety, 2015, 111: 102-08.
7.Huang Y, Wang XL, Zhang JW, Wu K *. Impact of Endocrine-Disrupting Chemicals on Reproductive Function in Zebrafish (Danio Rerio). Reprod Domest Anim, 2015, 50: 1-6.
8.Zhuang W, Wu K *, Wang Y, Zhu H, Deng Z, Peng L, Zhu G. Association of Serum Bisphenol-a Concentration and Male Reproductive Function among Exposed Workers. Arch Environ Contam Toxicol, 2015, 68: 38-45.
9.Huang Y, Ni W, Chen Y, Wang X, Zhang J, Wu K *. Levels and Risk Factors of Antimony Contamination in Human Hair from an Electronic Waste Recycling Area, Guiyu, China. Environ Sci Pollut Res Int, 2015, 22(9): 7112-7119.
10.Ni W, Huang Y, Wang X, Zhang J, Wu K *. Associations of neonatal lead, cadmium, chromium and nickel co-exposure with DNA oxidative damage in an electronic waste recycling town. Science of The Total Environment, 2014, 472: 354-62.
11.Ni W, Chen Y, Huang Y, Wang X, Zhang G, Luo J, Wu K *. Hair mercury concentrations and associated factors in an electronic waste recycling area, Guiyu, China. Environmental Research, 2014. 128(1): 84-91.
12.Wu K, Xu X, Peng L, Liu J, Guo Y, Huo X. Association between maternal exposure to perfluorooctanoic acid (PFOA) from electronic waste recycling and neonatal health outcomes. Environment International, 2012. 48(1): 1-8.
13.Wu K, Xu X, Liu J, Guo Y, Li Y, Huo X. Polybrominated Diphenyl Ethers in Umbilical Cord Blood and Relevant Factors in Neonates from Guiyu, China. Environmental Science & Technology, 2010. 44(2): 813-819
14.Wu K, Xu X, Liu J, Guo Y, Huo X. In utero exposure to polychlorinated biphenyls and reduced neonatal physiological development from Guiyu, China. Ecotoxicology and Environmental Safety, 2011. 74(8): 2141-2147.
15.Wu K, Su D, Lin K, Luo J, Au WW. XRCC1 Arg399Gln gene polymorphism and breast cancer risk: a meta- analysis based on case-control studies. Asian Pacific Journal of Cancer Prevention, 2011. 12(9): 2303-2309.
16.Wu K, Li K. Association between esophageal cancer and drought in China by using Geographic Information System. Environment International, 2007. 33(5): 603-8.
17.Wu KS, Huo X, Zhu GH. Relationships between esophageal cancer and spatial environment factors by using Geographic Information System. Science of The Total Environment, 2008. 393(2-3): 219-225.
18.Wu KS, Huo X, Zhu GH. Soil and Vegetation Characteristics of High- and Low-risk Areas of Esophageal Cancer in China. Asian Pacific Journal of Cancer Prevention, 2007. 8(4): 597-601.
19.Zheng L#, Wu K#, Li Y, Qi Z, Han D, Zhang B, Gu C, Chen G, Liu J, Chen S, Xu X, Huo X. Blood lead and cadmium levels and relevant factors among children from an e-waste recycling town in China. Environmental Research, 2008. 108(1): 15-20.
20.Du PL, Wu KS, Fang JY, Zeng Y, Xu ZX, Tang WR, Xu XL, Lin K. Cervical Cancer Mortality Trends in China, 1991-2013, and Predictions for the Future. Asian Pac J Cancer Prev 2015; 16(15): 6391-6.
21.Xu ZX, Lin ZX, Fang JY, Wu KS, Du PL, Zeng Y, Tang WR, Xu XL, Lin K. Mortality Characteristic and Prediction of Nasopharyngeal Carcinoma in China from 1991 to 2013. Asian Pac J Cancer Prev 2015; 16(15): 6729-34.
22.Fang JY, Dong HL, Wu KS, Du PL, Xu ZX, Lin K. Characteristics and Prediction of Lung Cancer Mortality in China from 1991 to 2013. Asian Pac J Cancer Prev 2015; 16: 5829-34.
23.Fang JY, Dong HL, Sang XJ, Xie B, Wu KS, Du PL, Xu ZX, Jia XY, Lin K. Colorectal Cancer Mortality Characteristics and Predictions in China, 1991-2011. Asian Pac J Cancer Prev, 2015, 16 (17), 7991-7995.
24.Guo Y, Huo X, Wu K, Liu JX, Zhang Y, Xu X. Carcinogenic polycyclic aromatic hydrocarbons in umbilical cord blood of human neonates from Guiyu, China. Science of The Total Environment, 2012. 427-428(1): 35-40.
25.Liu JX, Xu X, Wu KS, Piao ZX, Huang JR, Guo Y, Li W, Zhang Y, Chen A, Huo X. Association between lead exposure from electronic waste recycling and child temperament alterations. NeuroToxicology. 2011. 32(5): 458-464.
26.Guo Y, Huo X, Li Y, Wu K, Liu JX, Huang JR, Zheng G, Xiao Q, Yang H, WAng Y, Chen A, Xu X. Monitoring of lead, cadmium, chromium and nickel in placenta from an e-waste recycling town in China. Science of the Total Environment. 2010, 408(16): 3113-3117.
27.Guo Y, Wu K, Huo X, Xu X. Sources, Distribution, and Toxicity of Polycyclic Aromatic Hydrocarbons. Journal of Environmental Health. 2011, 73(9): 22-25.
28.Zheng G, Xu X, Li B, Wu K, Yekeen TA, Huo X. Association between lung function in school children and exposure to three transition metals from an e-waste recycling area. J Expo Sci Environ Epidemiol, 2013. 23(1): 67-72.
29.Fang JY, Wu KS, Zeng Y, Tang WR, Du PL, Xu ZX, Xu XL, Luo JY, Lin K. Liver Cancer Mortality Characteristics and Trends in China from 1991 to 2012. Asian Pac J Cancer Prev, 2015, 16 (5): 1959-64.
30.Tang WR, Fang JY. Wu KS, Shi XJ, Luo JY, Lin K. Epidemiological Characteristics and Prediction of Esophageal Cancer Mortality in China from 1991 to 2012. Asian Pacific Journal of Cancer Prevention, 2014. 15(16): 6929-6934.
31.Shi XJ, Au WW, Wu KS, Chen LX, Lin K. Mortality characteristics and prediction of female breast cancer in China form 1991 to 2011. Asian Pacific Journal of Cancer Prevention, 2014. 15(6): 2785-2791.
32.Xu X, Yang H, Chen A, Zhou Y, Wu K, Liu J, Zhang Y, Huo X. Birth Outcomes Related to Informal E-waste Recycling in Guiyu, China. Reproductive Toxicology. 2012, 33(1): 94-98.
33.Li Y, Xu XJ, Wu KS, Chen GJ, Liu JX, Chen SJ, Gu CW, Zhang B, Zheng LK, Zheng MH, Huo X. Monitoring of lead load and its effect on neonatal behavioral neurological assessment scores in Guiyu, an electronic waste recycling town in China. Journal of Environmental Monitoring, 2008. 10(10): 1233-1238.
34.Li Y, Xu X, Liu J, Wu K, Gu C, Shao G, Chen S, Chen G, Huo X. The hazard of chromium exposure to neonates in Guiyu of China. Science of The Total Environment, 2008. 403(1-3): 99-104.
35.Huo X, Li Y, Xu XJ, Wu KS, Liu JX, Chen SJ, Chen GJ, Huang JR. Toxic heavy metal waste exposure and abnormal birth outcomes in an electronic waste recycling town of China. Abstracts of the 45th Congress of the European Societies of Toxicology. Toxicology Letters, 2008. 180(Supplement 1): S185
36.Gu C, Chen S, Xu X, Zheng L, Li Y, Wu K, Liu J, Huo X. Lead and Cadmium Synergistically Enhance the Expression of Divalent Metal Transporter 1 Protein in Central Nervous System of Developing Rats. Neurochemical Research, 2009. 34(6): 1150-1156.
37.Zhang C, Li K, Wei L, Li Z, Yu P, Teng L, Wu K, Zhu J. p300 expression repression by hypermethylation associated with tumour invasion and metastasis in oesophageal squamous cell carcinoma. Journal of Clinical Pathology, 2007. 60(11): 1249-53.
38.Huang J, Xu X, Zheng G, Wu K, Guo Y, Liu J, Ban H, Liao W, Liu W, Yang H, Xiao Q, Wang Y, Huo X. Inverse Relationship between Urinary Retinol-Binding Protein, Beta-2-Microglobulin, and Blood Manganese Levels in School-Age Children from an E-Waste Recycling Town. Chapter •August 2012, DOI: 10.1201/b12531-12, In book: Environmental Contamination, pp.183-192