Search Ontology:
ChEBI

ketorolac

Term ID
CHEBI:6129
Synonyms
  • (+-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
  • (+-)-ketorolac
  • ketorolac
  • ketorolaco
  • ketorolacum
  • rac-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
  • rac-ketorolac
Definition
A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_part
has_role
inverse is_conjugate_base_of
is_conjugate_acid_of
Phenotype
Phenotype resulting from ketorolac
Phenotype where environments contain ketorolac
Phenotype modified by environments containing ketorolac
Human Disease / Model Data
Citations
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