(R)-ketorolac

Term ID

CHEBI:76227

Synonyms

(+)-ketorolac
(1R)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
(R)-(+)-ketorolac

Definition

A 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid that has R configuration. Unlike the S-enantiomer, it does not exhibit COX1 and COX2 inhibition, but does exhibit analgesic activity. Racemic ketorolac, known simply as ketorolac, is used (mainly as a tromethamine salt) as a potent analgesic for the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid Show first 5 Terms
has_role: analgesic

analgesic Show first 5 Terms
inverse has_part: ketorolac

ketorolac Show first 5 Terms
inverse is_enantiomer_of: (S)-ketorolac

(S)-ketorolac Show first 5 Terms
is_enantiomer_of: (S)-ketorolac

(S)-ketorolac Show first 5 Terms

Phenotype

Phenotype resulting from (R)-ketorolac

Phenotype where environments contain (R)-ketorolac

Phenotype modified by environments containing (R)-ketorolac

Human Disease / Model Data

Citations