OBO ID: DOID:684
Term Name: hepatocellular carcinoma Search Ontology:
Synonyms:
  • adult primary hepatocellular carcinoma
  • Hepatoma
Definition: A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver. (3)
References:
  • EFO:0000182
  • ICD10CM:C22.0
  • ICDO:M8170/3
  • NCI:C3099
  • OMIM:114550
  • ORDO:88673
  • SNOMEDCT_US_2019_09_01:109841003
Ontology: Human Disease   (DOID:684)
Relationships
is a type of:
has subtype:
OTHER hepatocellular carcinoma PAGES
GENES INVOLVED
Human Gene Zebrafish Ortholog OMIM Term OMIM Phenotype ID
APC Hepatoblastoma, somatic 114550
AXIN1 Hepatocellular carcinoma, somatic 114550
CASP8 Hepatocellular carcinoma, somatic 114550
CTNNB1 Hepatocellular carcinoma, somatic 114550
IGF2R Hepatocellular carcinoma, somatic 114550
MET Hepatocellular carcinoma, childhood type, somatic 114550
PDGFRL Hepatocellular cancer, somatic 114550
PIK3CA Hepatocellular carcinoma, somatic 114550
TP53 Hepatocellular carcinoma, somatic 114550
ZEBRAFISH MODELS
Fish Conditions Citations
WT chemical treatment by environment: doxycycline Yang et al., 2019
cancer xenotransplantation Tonon et al., 2016
gz24Tg chemical treatment: mifepristone Zheng et al., 2014
gz25Tg chemical treatment: doxycycline monohydrate Zheng et al., 2014
gz26Tg chemical treatment: doxycycline monohydrate Zheng et al., 2014
gz32Tg chemical treatment by environment: doxycycline Li et al., 2019
chemical treatment by environment: doxycycline Yang et al., 2017
chemical treatment: doxycycline Yan et al., 2017
chemical treatment: doxycycline monohydrate Yan et al., 2015
chemical treatment: doxycycline monohydrate Chew et al., 2014
chemical treatment by environment: doxycycline Li et al., 2017
chemical treatment: doxycycline Yan et al., 2017
gz36Tg chemical treatment by environment: mifepristone Yan et al., 2017
gz37Tg chemical treatment: doxycycline Huo et al., 2019
nn1005Tg standard conditions Lu et al., 2014
nn1006Tg standard conditions Tu et al., 2017
nn1010Tg standard conditions Su et al., 2019
nn1011Tg standard conditions Su et al., 2019
y1Tg cancer xenotransplantation Tonon et al., 2016
gz15Tg; gz26Tg chemical treatment: doxycycline Yan et al., 2017
gz25Tg ; gz38Tg chemical treatment by environment: doxycycline, chemical treatment by environment: afimoxifene Li et al., 2019
gz25Tg/+; gz26Tg/+ chemical treatment: doxycycline Li et al., 2015
tp53zdf1/zdf1 ; nn1004Tg ; nn1002Tg control Lin et al., 2019
tp53zdf1/zdf1; nn1002Tg control Lin et al., 2019
tp53zdf1/zdf1; nn1004Tg control Lin et al., 2019
mitfab692/b692 ; zf1047Tg/zf1047Tg ; ednrbab140/b140 standard conditions Huang et al., 2017
mitfaw2/w2; mpv17a9/a9 cancer xenotransplantation Bartucci et al., 2017
mpv17b18/b18 ; gz32Tg ; mitfaw2/w2 control Kumar et al., 2016
PHENOTYPE No data available

CITATIONS (35)
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.