ZFIN ChEBI: pemetrexed

OBO ID: CHEBI:63616

Term Name:	pemetrexed		Search Ontology:
Synonyms:	N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid pemetrexed
Definition:	An N-acylglutamic acid in which the N-acyl group is specified as 4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).
References:	CAS:137281-23-3 DrugBank:DB00642 KEGG:D07472 LINCS:LSM-6353 PMID:21129871 PMID:21831719 PMID:21900836 PMID:21937141 PMID:22021325 PMID:22116317 PMID:22124474 PMID:22134068 PMID:22201521 PMID:22223137 PMID:22237209 PMID:22240216 PMID:22243773 PMID:22244076 PMID:22258853 Patent:EP432677 Patent:US5344932 Reaxys:9097855 Wikipedia:Pemetrexed
Ontology:	ChEBI ( EBI )

Relationships

is a type of:	N-acyl-L-glutamic acid pyrrolopyrimidine N-acyl-L-glutamic acid pyrrolopyrimidine Show first 5 Terms
has_role:	antimetabolite antineoplastic agent EC 1.5.1.3 (dihydrofolate reductase) inhibitor EC 2.1.1.45 (thymidylate synthase) inhibitor EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor antimetabolite antineoplastic agent EC 1.5.1.3 (dihydrofolate reductase) inhibitor EC 2.1.1.45 (thymidylate synthase) inhibitor EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor Show first 5 Terms
inverse is_conjugate_base_of:	pemetrexed(2-) pemetrexed(2-) Show first 5 Terms
is_conjugate_acid_of:	pemetrexed(2-) pemetrexed(2-) Show first 5 Terms

PHENOTYPE No data available