ZFIN ID: ZDB-GENE-990706-8
Gene Name: GLI family zinc finger 2a
Gene Symbol: gli2a
Previous Names: gli2, etID12892.9 (1), fc85b05, wu:fc85b05 (1), yot, you too, you-too
Location: Chr: 9 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 28 figures from 19 publications
Directly Submitted Expression Data: 6 figures (22 images) from Thisse et al., 2005 [eu801]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  adaxial cell, adenohypophyseal placode, anterior neural plate, brain (all 39) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
gli2a_unspecified Unspecified Unknown Unknown
i275 Small Deletion Unknown Unknown ZINC_FINGER_NUCLEASE
i276 Insertion Unknown Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
la016571Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • s406 Unknown Unknown Unknown ENU
    sa10919 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12847 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa15237 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa15798 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa21538 Point Mutation Unknown Unknown ENU
    sa21539 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41479 Point Mutation Unknown Unknown ENU
    ty17a Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty119 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-gli2a (1), MO2-gli2a (1)
    PHENOTYPE
    Data: 44 figures from 27 publications
    Observed in: adaxial cell, adenohypophysis, adenohypophysis morphogenesis, adrenocorticotropic hormone secreting cell (all 71) expand
    DISEASE ASSOCIATED WITH gli2a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    holoprosencephaly Holoprosencephaly 9 610829
    Culler-Jones syndrome 615849
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process smoothened signaling pathway (more)
    Cellular Component nonmotile primary cilium (more)
    Molecular Function sequence-specific DNA binding (more)
    GO Terms (all 33)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR007087 (1)
  • InterPro:IPR013087 (1)
  • InterPro:IPR015880 (1)
  • PROSITE:PS00028 (1)
  • PROSITE:PS50157 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA gli2a-001 (1) 6039
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Ab1-gli2a (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM gli2a
    Tg(hsp70l:gli2aDR-EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    gli2aContained in: [BAC] CH211-61D13 (1) (order this), DKEY-25L23 (1) (order this)
    gli2aEncodes: [EST] eu801 (1), fc85b05 (1)
    [cDNA] MGC:195099 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130967 (1) 6070bp
    Genomic GenBank:BX548071 (1) 223099bp Blast at MegaBLAST
    Polypeptide UniProtKB:B0S6T1 (1) 1439aa
    Sequence Clusters UniGene:8091 (1)
    Sequence Information (all 21)
    OTHER gli2a GENE PAGES
  • Gene:30154 (1)
  • VEGA:OTTDARG00000020879 (1)
  • Ensembl(GRCz10):ENSDARG00000025641 (1)
  • ORTHOLOGY for gli2a (Chr: 9)
    Species Symbol Chromosome Accession # Evidence
    Human GLI2 2
  • Gene:2736
  • OMIM:165230
  • HGNC:4318
  • Amino acid sequence comparison (3)
    Conserved genome location (synteny) (3)
    Nucleotide sequence comparison (1)
    Mouse Gli2 1
  • MGI:95728
  • Gene:14633
  • Amino acid sequence comparison (3)
    Conserved genome location (synteny) (2)
    Other (1)
    Download Curated Orthology
    CITATIONS (140)