Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-990706-8
Gene Name: GLI-Kruppel family member GLI2a
Gene Symbol: gli2a
Previous Names: gli2, etID12892.9 (1), fc85b05, wu:fc85b05 (1), yot, you too, you-too
Nomenclature History
GENE EXPRESSION
All Expression Data: 24 figures from 15 publications
Directly Submitted Expression Data: 6 figures (22 images) from Thisse et al., 2005 [eu801]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  adenohypophyseal placode, anterior neural plate, central nervous system, choroidal fissure (all 29) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 13 genotypes
Alleles: gli2a_unspecified, la016571Tg, s406, sa10919, sa12847 (all 10) expand
Knockdown reagents: MO1-gli2a (1), MO2-gli2a (1)
PHENOTYPE
Data: 41 figures from 24 publications
Observed in: adaxial cell, adenohypophysis, adenohypophysis morphogenesis, adrenocorticotropic hormone secreting cell (all 66) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Holoprosencephaly-9 610829
GENE ONTOLOGY
Ontology GO Term
Biological Process 3'-UTR-mediated mRNA stabilization (more)
Cellular Component nonmotile primary cilium (more)
Molecular Function metal ion binding (more)
GO Terms (all 29)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR007087 (1)
  • InterPro:IPR013087 (1)
  • InterPro:IPR015880 (1)
  • PROSITE:PS00028 (1)
  • PROSITE:PS50157 (1)
  • Pfam:PF00096 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA gli2a-001 (1) 6039
    GENE PRODUCT DESCRIPTION No description available
    ANTIBODIES
    Ab1-gli2a (1)
    CONSTRUCTS WITH SEQUENCES FROM gli2a
    Tg(hsp70l:gli2aDR-EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    gli2a Contained in: [BAC] CH211-61D13 (1) (order this), DKEY-25L23 (1)
    gli2a Encodes: [EST] eu801 (1), fc85b05 (1)
    [cDNA] MGC:195099 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130967 (1) 6070 bp
    Genomic GenBank:BX548071 (1) 223099 bp Blast at MegaBLAST
    Polypeptide UniProtKB:B0S6T1 (1) 1439 aa
    Sequence Clusters UniGene:8091 (1)
    Sequence Information (all 21)
    OTHER gli2a GENE PAGES
  • Gene:30154 (1)
  • VEGA:OTTDARG00000020879 (1)
  • Ensembl(Zv9):ENSDARG00000025641 (1)
  • MAPPING INFORMATION
    Chr: 9 Details View Map: Merged   Individual Panels
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL XH
    Zebrafish gli2a 9  
    Human GLI2 2 (2q14)
  • OMIM:165230
  • Gene:2736
  • Mouse Gli2 1 ( 52.17 cM)
  • MGI:95728
  • Gene:14633
  • CITATIONS (126)