Gene
thrb
- ID
- ZDB-GENE-990415-268
- Name
- thyroid hormone receptor beta
- Symbol
- thrb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Enables nuclear receptor activity. Acts upstream of or within several processes, including inner ear development; retinal cone cell differentiation; and thyroid hormone mediated signaling pathway. Predicted to be located in nucleus. Is expressed in several structures, including brain; eye; gonad; liver; and optic vesicle. Used to study thyroid hormone resistance syndrome. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); cervix uteri carcinoma in situ; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Orthologous to human THRB (thyroid hormone receptor beta).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 30 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- af109732 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 29 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
selective pituitary thyroid hormone resistance | Alliance | Thyroid hormone resistance, selective pituitary | 145650 |
thyroid hormone resistance syndrome | Alliance | Thyroid hormone resistance | 188570 |
thyroid hormone resistance syndrome | Alliance | Thyroid hormone resistance, autosomal recessive | 274300 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
thyroid hormone resistance syndrome | AB + MO4-thrb | standard conditions | Marelli et al., 2016 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
Family | IPR001723 | Nuclear hormone receptor |
Family | IPR001728 | Thyroid hormone receptor |
Family | IPR050234 | Nuclear hormone receptor family NR1 subfamily |
Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR1 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Thyroid hormone receptor | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2B694
|
479 | |||||||
UniProtKB:S6BPQ3
|
488 | |||||||
UniProtKB:Q9PVE4
|
395 | |||||||
UniProtKB:A0A8M2B654
|
268 | |||||||
UniProtKB:A0A2R8QK91
|
508 | |||||||
UniProtKB:A0A8M9PN36
|
281 | |||||||
UniProtKB:A0A8M9PRA9
|
415 | |||||||
UniProtKB:A0A8M3AK49
|
240 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
aberrant processed transcript |
thrb-201
(1)
|
Ensembl | 1,992 nt | ||
mRNA |
thrb-203
(1)
|
Ensembl | 3,136 nt | ||
mRNA |
thrb-204
(1)
|
Ensembl | 5,600 nt | ||
mRNA |
thrb-205
(1)
|
Ensembl | 2,198 nt | ||
mRNA |
thrb-206
(1)
|
Ensembl | 5,732 nt | ||
mRNA |
thrb-207
(1)
|
Ensembl | 5,822 nt | ||
mRNA |
thrb-208
(1)
|
Ensembl | 5,804 nt | ||
mRNA |
thrb-209
(1)
|
Ensembl | 5,795 nt | ||
mRNA |
thrb-210
(1)
|
Ensembl | 5,629 nt | ||
ncRNA |
thrb-002
(1)
|
Ensembl | 1,234 nt |
Interactions and Pathways
No data available
Plasmids
No data available