Gene
neurod1
- ID
- ZDB-GENE-990415-172
- Name
- neuronal differentiation 1
- Symbol
- neurod1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity and protein dimerization activity. Involved in several processes, including endocrine pancreas development; negative regulation of Notch signaling pathway; and neuron differentiation. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in glucose intolerance; hyperglycemia; maturity-onset diabetes of the young type 6; type 1 diabetes mellitus; and type 2 diabetes mellitus. Is expressed in several structures, including endoderm; nervous system; neural plate; neurogenic placode; and pancreatic system. Orthologous to human NEUROD1 (neuronal differentiation 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 217 figures from 138 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| maturity-onset diabetes of the young type 6 | Alliance | Maturity-onset diabetes of the young 6 | 606394 |
| type 2 diabetes mellitus | Alliance | {Type 2 diabetes mellitus, susceptibility to} | 125853 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR022575 | Neurogenic differentiation factor, domain of unknown function |
| Family | IPR016637 | Neurogenic differentiation factor NeuroD |
| Family | IPR050359 | Basic helix-loop-helix transcription factors |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Basic helix-loop-helix transcription factors | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Neurogenic differentiation factor, domain of unknown function | Neurogenic differentiation factor NeuroD |
|---|---|---|---|---|---|---|
|
UniProtKB:O42202
|
350 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
neurod1-201
(1)
|
Ensembl | 2,422 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-neurod | monoclonal | Mouse |
|
11 | |||
| Ab3-neurod1 |
|
2 |
Plasmids
No data available