ZFIN ID: ZDB-GENE-990415-172
Gene Name: neuronal differentiation 1
Gene Symbol: neurod1    Nomenclature History

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Previous Names: neuro-D, neurod, nrd, Beta2/NeuroD (1), etID309883.9 (1), NDF1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have DNA binding activity and protein dimerization activity. Involved in several processes, including endocrine pancreas development; negative regulation of Notch signaling pathway; and neuron differentiation. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in glucose intolerance; hyperglycemia; maturity-onset diabetes of the young type 6; type 1 diabetes mellitus; and type 2 diabetes mellitus. Is expressed in several structures, including endoderm; nervous system; neural plate; neurogenic placode; and pancreatic system. Orthologous to human NEUROD1 (neuronal differentiation 1).
Genome Resources: Alliance (1),  Gene:30169 (1),  Ensembl(GRCz11):ENSDARG00000019566 (2)
GENE EXPRESSION
All Expression Data: 193 figures from 119 publications
Directly Submitted Expression Data: 12 figures (35 images) from Rauch et al., 2003 [cegs2212]
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-neurod1
2
MO1-neurod1 N/A 7
MO2-neurod1 N/A 2
MO3-neurod1 N/A 1
DISEASE ASSOCIATED WITH neurod1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
maturity-onset diabetes of the young type 6 Alliance Maturity-onset diabetes of the young 6 606394
type 2 diabetes mellitus Alliance {Diabetes mellitus, noninsulin-dependent} 125853
DISEASE ASSOCIATED WITH neurod1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process camera-type eye photoreceptor cell development (more)
Cellular Component cytoplasm (more)
Molecular Function DNA binding (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA neurod1-201 (1)    Ensembl 2422
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-neurod monoclonal Mouse IHC 8
Ab3-neurod1 WB 2
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM neurod1
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(-2.5neurod1:EGFP) neurod1 EGFP Danio rerio 1 7
Tg(-5kbneurod1:GGECO) neurod1 Danio rerio 1 2
Tg(-5kbneurod1:MITO-mEos) neurod1 EosMITO Danio rerio 1 1
Tg(-5kbneurod1:MITO-RGECO) neurod1 MITORGECO Danio rerio 1 2
Tg(hsp70l:neurod-EGFP) hsp70l EGFPneurod1 Danio rerio 3 2
tg(neurod1:gal4) neurod1 GAL4 Danio rerio 1 2
Tg(neurod1:GCaMP6F) neurod1 GCaMP Danio rerio 1 5
tg(neurod1:lox2272-loxp-tomato-lox2272-cerulean-loxp-eyfp) neurod1 CeruleanEYFPLOX2272LOXPTomato Danio rerio 1 1
Tg(neurod1:nsfa-EGFP) neurod1 EGFPnsfa Danio rerio 1 3
tg(neurod1:sypb-mscarlet) neurod1 mScarletsypb Danio rerio 1 1
Tg(neurod1:TagRFP) neurod1 TagRFP Danio rerio 1 12
Tg(neurod1:tetxlc) neurod1 tetxlc Danio rerio 1 1
Tg(neurod1:Tomato) neurod1 Tomato Danio rerio 1 1
TgBAC(neurod1:EGFP) neurod1 EGFP Danio rerio 1 93
TgBAC(neurod1:KALTA4) neurod1 KALTA4 Danio rerio 1 2
MARKER RELATIONSHIPS
neurod1 Contained in: [BAC] DKEY-165L22 (1) (order this)
neurod1 Encodes: [EST] cegs2212 (1) (order this)
[cDNA] MGC:65901 (1), MGC:77342 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_130978 (1) 2158 nt
Genomic GenBank:CR753862 (1) 201337 nt Blast at MegaBLAST
Polypeptide UniProtKB:O42202 (1) 350 aa
Sequence Information (all 20)
ORTHOLOGY for neurod1 ( Chr: 9 )
CITATIONS (242)