Gene

neurod1

ID
ZDB-GENE-990415-172
Name
neuronal differentiation 1
Symbol
neurod1 Nomenclature History
Previous Names
  • neuro-D
  • neurod
  • nrd
  • Beta2/NeuroD (1)
  • etID309883.9 (1)
  • NDF1 (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including endocrine pancreas development; negative regulation of Notch signaling pathway; and sensory organ development. Predicted to localize to nucleus. Is expressed in several structures, including endoderm; nervous system; neural plate; neurogenic placode; and pancreatic system. Human ortholog(s) of this gene implicated in glucose intolerance; hyperglycemia; maturity-onset diabetes of the young type 6; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human NEUROD1 (neuronal differentiation 1).
Genome Resources
Note
None
Expression
All Expression Data
194 figures from 120 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With neurod1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
maturity-onset diabetes of the young type 6 Alliance Maturity-onset diabetes of the young 6 606394
type 2 diabetes mellitus Alliance {Type 2 diabetes mellitus, susceptibility to} 125853
Associated With neurod1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Domain IPR022575 Neurogenic differentiation factor, domain of unknown function
Family IPR016637 Neurogenic differentiation factor NeuroD
Family IPR032652 Neurogenic differentiation factor 1
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily Myc-type, basic helix-loop-helix (bHLH) domain Neurogenic differentiation factor 1 Neurogenic differentiation factor, domain of unknown function Neurogenic differentiation factor NeuroD
UniProtKB:I6L9F5 269
UniProtKB:O42202 350
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-neurod monoclonal Mouse
  • IHC
8
Ab3-neurod1
  • WB
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations