Gene

myca

ID

ZDB-GENE-990415-162

Name

MYC proto-oncogene, bHLH transcription factor a

Symbol

myca Nomenclature History

Previous Names

c-myc (1)
cmyc
cmyca
C-Myc1 (1)
zc-myc (1)

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in hematopoietic stem cell differentiation; regulation of vasculature development; and vasculature development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); demyelinating disease; hematologic cancer (multiple); prostate cancer (multiple); and urinary bladder cancer. Is expressed in several structures, including digestive system; immature eye; nervous system; neural tube; and pronephros. Orthologous to human MYC (MYC proto-oncogene, bHLH transcription factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

75 figures from 58 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:64149 (5 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Shi et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myca Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Burkitt lymphoma	Alliance	Burkitt lymphoma, somatic	113970

Associated With myca Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003327	Leucine zipper, Myc
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Domain	IPR012682	Transcription regulator Myc, N-terminal
Family	IPR002418	Transcription regulator Myc
Family	IPR050433	Myc family transcription factors
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily